Reduction in saturated fat intake improves cardiovascular risks in obese adolescents during interdisciplinary therapy

Reduction in saturated fat intake improves cardiovascular risks in obese adolescents during interdisciplinary therapy

Autor Masquio, D. C. L. Autor UNIFESP Google Scholar
Piano, A. de Autor UNIFESP Google Scholar
Campos, R. M. S. Autor UNIFESP Google Scholar
Sanches, P. L. Autor UNIFESP Google Scholar
Carnier, J. Autor UNIFESP Google Scholar
Corgosinho, F. C. Autor UNIFESP Google Scholar
Netto, B. D. M. Autor UNIFESP Google Scholar
Carvalho-Ferreira, J. P. Autor UNIFESP Google Scholar
Oyama, L. M. Autor UNIFESP Google Scholar
Oller do Nascimento, C. M. Autor UNIFESP Google Scholar
Tock, L. Google Scholar
Mello, M. T. de Autor UNIFESP Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Damaso, A. R. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Weight Sci
Resumo Background/ObjectivesObesity is related to inflammation and cardiovascular disease. the increase in saturated fatty acid intake (SFA) can potentiate cardiovascular risks. the aim of this study was to assess the influence of change in SFA on carotid intima-media thickness (cIMT), metabolic profile and anti/pro-inflammatory adipokines in obese adolescents.MethodsSixty obese adolescents were subjected to 1year of interdisciplinary intervention (nutrition, psychology, physical exercise and clinical therapy). Blood glucose, insulin, lipid profile, leptin and adiponectin were analysed. Insulin resistance was estimated by HOMA-IR and HOMA-AD. cIMT was measured by ultrasonography. Dietetic intake was calculated by 3-day dietary record. Volunteers were analysed according to tertiles of change () in SFA intake: Low-SFA reduction <3.68g; Moderate-SFA reduction 3.68-13.67g; and High-SFA reduction >13.67g.ResultsModerate and High-SFA tertiles presented reduction in insulin, leptin/adiponectin ratio, cIMT and increase in adiponectin and adiponectin/leptin ratio. Adiponectin/leptin ratio was predictor of cIMT. HOMA-IR, total cholesterol and LDL-cholesterol reduced only in High-SFA tertile, and was associated with SFA independent of visceral fat. Negative correlations between of SFA and adiponectin and adiponectin/leptin ratio were observed.ConclusionObese adolescents with moderate and high reduction in SFA presented improvements on pro/anti-inflammatory biomarkers and cIMT, leading to reduction in cardiovascular risks.
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
UNIFESP
AFIP
CEPE
CEMSA
Número do financiamento CNPq: 141533/2012-9
CAPES: AUX-PE-PNPD 2566/2011
FAPESP: 2013/041364
Data de publicação 2015-05-01
Publicado em International Journal of Clinical Practice. Hoboken: Wiley-Blackwell, v. 69, n. 5, p. 560-570, 2015.
ISSN 1368-5031 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 560-570
Fonte http://dx.doi.org/10.1111/ijcp.12573
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000353962200008
Endereço permanente http://repositorio.unifesp.br/handle/11600/39074

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