Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures

Autor Phan, Isabelle Q. H. Google Scholar
Davies, Douglas R. Google Scholar
Moretti, Nilmar Silvio Autor UNIFESP Google Scholar
Shanmugam, Dhanasekaran Google Scholar
Cestari, Igor Google Scholar
Anupama, Atashi Google Scholar
Fairman, James W. Google Scholar
Edwards, Thomas E. Google Scholar
Stuart, Kenneth Google Scholar
Schenkman, Sergio Autor UNIFESP Google Scholar
Myler, Peter J. Google Scholar
Instituição SSGCID
Seattle Biomed Res Inst
Beryllium
Universidade Federal de São Paulo (UNIFESP)
CSIR Natl Chem Lab
Resumo Prior studies have highlighted the potential of superoxide dismutases as drug targets in eukaryotic pathogens. This report presents the structures of three iron-dependent superoxide dismutases (FeSODs) from Trypanosoma cruzi, Leishmania major and Babesia bovis. Comparison with existing structures from Plasmodium and other trypanosome isoforms shows a very conserved overall fold with subtle differences. in particular, structural data suggest that B. bovis FeSOD may display similar resistance to peroxynitrite-mediated inactivation via an intramolecular electron-transfer pathway as previously described in T. cruzi FeSOD isoform B, thus providing valuable information for structure-based drug design. Furthermore, lysine-acetylation results in T. cruzi indicate that acetylation occurs at a position close to that responsible for the regulation of acetylation-mediated activity in the human enzyme.
Palavra-chave iron superoxide dismutase
Trypanosoma
Apicomplexa
Idioma Inglês
Financiador Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
National Institutes of Health
American Heart Association
Número do financiamento Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services: HHSN272201200025C
FAPESP: 2012/09403-8
FAPESP: 2013/20074-9
FAPESP: 2011/51973-3
National Institutes of Health: R01 AI078962
American Heart Association: 14POST18970046
Data de publicação 2015-05-01
Publicado em Acta Crystallographica Section F-structural Biology Communications. Hoboken: Wiley-Blackwell, v. 71, p. 615-621, 2015.
ISSN 1744-3091 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 615-621
Fonte http://dx.doi.org/10.1107/S2053230X15004185
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000354378200018
Endereço permanente http://repositorio.unifesp.br/handle/11600/39070

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