The role of progesterone in memory: An overview of three decades

The role of progesterone in memory: An overview of three decades

Author Barros, L. A. Autor UNIFESP Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Andersen, M. L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Memory comprises acquisition, consolidation and retrieval of information. Many substances can influence these different phases. It is well demonstrated that sex hormones, mainly estrogen, impact cognitive function. More recently, progesterone has also been documented as playing an important role in cognition, since it influences brain regions involved in memory. Currently, many women are under hormone treatment, which contain progesterone to decrease the risk of development of endometrial cancer. This affords the opportunity to study the real effects of this hormonal replacement on cognition. There are many contradictory results regarding the role of progesterone in memory. Therefore, the aim of this review was to synthesize these studies using the new perspective of the influence of hormone replacement on cognition in women. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Progesterone
Sex hormones
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2013/14422-4
Date 2015-02-01
Published in Neuroscience and Biobehavioral Reviews. Oxford: Pergamon-Elsevier B.V., v. 49, p. 193-204, 2015.
ISSN 0149-7634 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 193-204
Access rights Closed access
Type Review
Web of Science ID WOS:000349592400017

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