Accelerated partial irradiation for breast cancer: Systematic review and meta-analysis of 8653 women in eight randomized trials

Accelerated partial irradiation for breast cancer: Systematic review and meta-analysis of 8653 women in eight randomized trials

Author Marta, Gustavo Nader Google Scholar
Macedo, Cristiane Rufino de Autor UNIFESP Google Scholar
Carvalho, Heloisa de Andrade Google Scholar
Hanna, Samir Abdallah Google Scholar
Fernandes da Silva, Joao Luis Google Scholar
Riera, Rachel Autor UNIFESP Google Scholar
Institution Hosp Sirio Libanes
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background and purpose: Accelerated partial breast irradiation (APBI) is the strategy that allows adjuvant treatment delivery in a shorter period of time in smaller volumes. This study was undertaken to assess the effectiveness and outcomes of APBI in breast cancer compared with whole-breast irradiation (WBI). Material and methods: Systematic review and meta-analysis of randomized controlled trials of WBI versus APBI. Two authors independently selected and assessed the studies regarding eligibility criteria. Results: Eight studies were selected. A total of 8653 patients were randomly assigned for WBI versus APBI. Six studies reported local recurrence outcomes. Two studies were matched in 5 years and only one study for different time of follow-up. Meta-analysis of two trials assessing 1407 participants showed significant difference in the WBI versus APBI group regarding the 5-year local recurrence rate (HR = 4.54, 95% CI: 1.78-11.61, p = 0.002). Significant difference in favor of WBI for different follow-up times was also found. No differences in nodal recurrence, systemic recurrence, overall survival and mortality rates were observed. Conclusions: APBI is associated with higher local recurrence compared to WBI without compromising other clinical outcomes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Keywords Breast cancer
Breast-conserving therapy
Whole-breast irradiation
Accelerated partial breast irradiation
Language English
Date 2015-01-01
Published in Radiotherapy and Oncology. Clare: Elsevier B.V., v. 114, n. 1, p. 42-49, 2015.
ISSN 0167-8140 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 42-49
Origin http://dx.doi.org/10.1016/j.radonc.2014.11.014
Access rights Closed access
Type Review
Web of Science ID WOS:000350937500008
URI http://repositorio.unifesp.br/handle/11600/38593

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