Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

Author Moreno, Mayara Franzoi Autor UNIFESP Google Scholar
De Laquila, Rachel Autor UNIFESP Google Scholar
Okuda, Marcos Hiromu Autor UNIFESP Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Souza, Gabriel Inacio de Morais Honorato de Autor UNIFESP Google Scholar
Souza, Claudio Teodoro de Google Scholar
Telles, Monica Marques Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Integradas Coracao Jesus FAINC
Univ Estadual Paulista
Univ Southern Santa Catarina
Abstract Background: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. the consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.
Keywords High-fat diet
Adipokines
Adipose tissue
Inflammation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
FAINC
Grant number FAPESP: 2009/14373-8
Date 2014-08-12
Published in Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014.
ISSN 1758-5996 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 7
Origin http://dx.doi.org/10.1186/1758-5996-6-84
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000340957000002
URI http://repositorio.unifesp.br/handle/11600/38086

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