Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions

Fibromyalgia and Sleep in Animal Models: A Current Overview and Future Directions

Autor Frange, Cristina Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Araujo, Paula Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Sleep disorders are highly prevalent in patients with fibromyalgia (FM). Many of the daytime symptoms, such as chronic pain and fatigue, may be related to the non-restorative sleep patterns associated with the disease. Pain influences the sleep process and sleep disturbances decrease the pain threshold in a reciprocal framework. Thus, understanding the link between sleep and FM has become an important research topic in basic science. Therefore, in the current review we connect these topics and provide some insights into the cyclic relationship between sleep and pain, which has been addressed mainly in animal models. Additionally, we highlight the urgent need for sleep studies in FM animal models, which might improve the knowledge base and accelerate advances in this field.
Assunto Sleep
Fibromyalgia
Animal models
Chronic pain
Allodynia
Hyperalgesia
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 10/50130-0
Data 2014-08-01
Publicado em Current Pain and Headache Reports. New York: Springer, v. 18, n. 8, 10 p., 2014.
ISSN 1531-3433 (Sherpa/Romeo, fator de impacto)
Editor Springer
Extensão 10
Fonte http://dx.doi.org/10.1007/s11916-014-0434-3
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000340092100001
URI http://repositorio.unifesp.br/handle/11600/38038

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