The action of CGRP and SP on cultured skin fibroblasts

The action of CGRP and SP on cultured skin fibroblasts

Author Hochman, Bernardo Autor UNIFESP Google Scholar
Tucci-Viegas, Vanina Monique Autor UNIFESP Google Scholar
Monteiro, Paola K. P. Autor UNIFESP Google Scholar
Franca, Jeronimo Pereira de Autor UNIFESP Google Scholar
Gaiba, Silvana Autor UNIFESP Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Estadual Santa Cruz
Abstract Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in the skin, followed by substance P (SP), vasoactive intestinal peptide (VIP), and other neuropeptides in smaller amounts. the proliferative effect of neuropeptides on fibroblasts may affect wound healing and may be associated with hyperproliferative skin and mesenchymal disorders. Understanding the neuropeptidergic action on fibroblasts may provide relevant information to a deeper comprehension of the healing process. This study reviews the action of the main neuropeptides, CGRP and SP, on cultured human skin fibroblasts.A systematic literature search was conducted on Medline and Web of Science databases on December 21, 2013.A total of 74 articles were retrieved using the proposed search strategies and 3 were found in the references section of the selected articles. Thirteen of the retrieved articles studied the action of CGRP and SP on cultured human skin fibroblasts, 12 of which related to SP and 1 related to both CGRP and SP.Only one study was retrieved about the action of both CGRP and SP on cultured human skin fibroblasts. Further studies are necessary to investigate CGRP on skin fibroblasts and its role in the fibroplasia phase of wound healing.
Keywords Calcitonin gene-related peptide
Substance P
Wound healing
Language English
Date 2014-07-01
Published in Central European Journal of Biology. Warsaw: de Gruyter Open Ltd, v. 9, n. 7, p. 717-726, 2014.
ISSN 1895-104X (Sherpa/Romeo, impact factor)
Publisher De Gruyter Open Ltd
Extent 717-726
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000335495900007

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