Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus

Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus

Author Blois, Sandra M. Google Scholar
Gueuvoghlanian-Silva, Barbara Y. Autor UNIFESP Google Scholar
Tirado-Gonzalez, Irene Google Scholar
Torloni, Maria Regina Autor UNIFESP Google Scholar
Freitag, Nancy Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Conrad, Melanie L. Google Scholar
Unverdorben, Laura Google Scholar
Barrientos, Gabriela Google Scholar
Knabl, Julia Google Scholar
Toldi, Gergely Google Scholar
Molvarec, Attila Google Scholar
Rose, Matthias Google Scholar
Markert, Udo R. Google Scholar
Jeschke, Udo Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Institution Med Univ Berlin
Universidade Federal de São Paulo (UNIFESP)
Univ Hosp Jena
Univ Munich
Semmelweis Univ
Abstract Galectin-1 (gal-1) is a prototype carbohydrate-binding protein, whose dysregulation is associated with adverse pregnancy outcomes such as spontaneous abortion and pre-eclampsia. Furthermore, it is known that faulty gal-1 protein production or gene regulation can be caused by single-nucleotide polymorphisms in the LGALS1 gene. Gestational diabetes mellitus (GDM) is also an adverse pregnancy outcome and the most common metabolic disorder during gestation. However, gal-1 expression patterns during GDM remain largely unknown. Our aims were to define local and peripheral gal-1 expression patterns during pregnancy, and to investigate LGALS1 gene polymorphisms in GDM patients. Circulating gal-1 levels were determined by ELISA in GDM patients and normal pregnant controls, and LGALS1 gene polymorphisms were assessed for association with GDM. Placental tissues were collected from control and GDM term pregnancies to evaluate local gal-1 expression by immunofluorescence. Our results show that GDM is associated with a failure to increase circulating gal-1 levels during the second and third trimester, as well as overexpression of gal-1 in placental tissue. Additionally, the LGALS1 polymorphism rs4820294 was associated with the development of GDM. in pregnancies complicated by GDM, we observed gal-1 dysregulation both locally in the placenta and peripherally in the circulation. Furthermore, the association between the LGALS1 polymorphism and GDM may indicate a genetic contribution to this adverse pregnancy outcome.
Keywords galectin-1
gestational diabetes
glucose
Language English
Sponsor Fritz Thyssen Stiftung
Charite Stiftung
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Semmelweis University (Hungary)
Thuringian Ministry for Education, Science and Arts
Charite fellowship
Rachel Hirsch Habilitation fellowship
Charite doctoral fellowship
German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number Fritz Thyssen Stiftung: Az.10.10.2.125
FAPESP: 11/14554-2
Date 2014-07-01
Published in Molecular Human Reproduction. Oxford: Oxford Univ Press, v. 20, n. 7, p. 644-649, 2014.
ISSN 1360-9947 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 644-649
Origin http://dx.doi.org/10.1093/molehr/gau021
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000339424400005
URI http://repositorio.unifesp.br/handle/11600/37891

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