Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma?

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dc.contributor.author Braga, Walter M. T.
dc.contributor.author Silva, Bruna R. da [UNIFESP]
dc.contributor.author Alves, Veruska L. F. [UNIFESP]
dc.contributor.author Bortoluzo, Adriana B.
dc.contributor.author Atanackovic, Djordje
dc.contributor.author Colleoni, Gisele W. B. [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:17Z
dc.date.available 2016-01-24T14:37:17Z
dc.date.issued 2014-05-01
dc.identifier http://dx.doi.org/10.2217/IMT.14.24
dc.identifier.citation Immunotherapy. London: Future Medicine Ltd, v. 6, n. 5, p. 569-575, 2014.
dc.identifier.issn 1750-743X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37757
dc.description.abstract Aim: the present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials & methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 569-575
dc.language.iso eng
dc.publisher Future Medicine Ltd
dc.relation.ispartof Immunotherapy
dc.rights Acesso restrito
dc.subject cancer/testis antigen en
dc.subject multiple myeloma en
dc.subject Th17 en
dc.subject Treg en
dc.title Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma? en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Insper Inst Educ & Res
dc.contributor.institution Univ Med Ctr Hamburg Eppendorf
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, Dept Oncol Clin & Expt, São Paulo, Brazil
dc.description.affiliation Insper Inst Educ & Res, São Paulo, Brazil
dc.description.affiliation Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, Dept Oncol Clin & Expt, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2010/17668-6
dc.identifier.doi 10.2217/IMT.14.24
dc.description.source Web of Science
dc.identifier.wos WOS:000337220000012



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