Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma?

Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma?

Author Braga, Walter M. T. Google Scholar
Silva, Bruna R. da Autor UNIFESP Google Scholar
Alves, Veruska L. F. Autor UNIFESP Google Scholar
Bortoluzo, Adriana B. Google Scholar
Atanackovic, Djordje Google Scholar
Colleoni, Gisele W. B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Insper Inst Educ & Res
Univ Med Ctr Hamburg Eppendorf
Abstract Aim: the present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials & methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM.
Keywords cancer/testis antigen
multiple myeloma
Th17
Treg
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/17668-6
Date 2014-05-01
Published in Immunotherapy. London: Future Medicine Ltd, v. 6, n. 5, p. 569-575, 2014.
ISSN 1750-743X (Sherpa/Romeo, impact factor)
Publisher Future Medicine Ltd
Extent 569-575
Origin http://dx.doi.org/10.2217/IMT.14.24
Access rights Closed access
Type Article
Web of Science ID WOS:000337220000012
URI http://repositorio.unifesp.br/handle/11600/37757

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