Strategies to manage hepatitis C virus (HCV) disease burden

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dc.contributor.author Wedemeyer, H.
dc.contributor.author Duberg, A. S.
dc.contributor.author Buti, M.
dc.contributor.author Rosenberg, W. M.
dc.contributor.author Frankova, S.
dc.contributor.author Esmat, G.
dc.contributor.author Ormeci, N.
dc.contributor.author Van Vlierberghe, H.
dc.contributor.author Gschwantler, M.
dc.contributor.author Akarca, U.
dc.contributor.author Aleman, S.
dc.contributor.author Balik, I.
dc.contributor.author Berg, T.
dc.contributor.author Bihl, F.
dc.contributor.author Bilodeau, M.
dc.contributor.author Blasco, A. J.
dc.contributor.author Brandao Mello, C. E.
dc.contributor.author Bruggmann, P.
dc.contributor.author Calinas, F.
dc.contributor.author Calleja, J. L.
dc.contributor.author Cheinquer, H.
dc.contributor.author Christensen, P. B.
dc.contributor.author Clausen, M.
dc.contributor.author Coelho, H. S. M.
dc.contributor.author Cornberg, M.
dc.contributor.author Cramp, M. E.
dc.contributor.author Dore, G. J.
dc.contributor.author Doss, W.
dc.contributor.author El-Sayed, M. H.
dc.contributor.author Ergor, G.
dc.contributor.author Estes, C.
dc.contributor.author Falconer, K.
dc.contributor.author Felix, J.
dc.contributor.author Ferraz, Maria Lucia Gomes [UNIFESP]
dc.contributor.author Ferreira, Paulo Roberto [UNIFESP]
dc.contributor.author Garcia-Samaniego, J.
dc.contributor.author Gerstoft, J.
dc.contributor.author Giria, J. A.
dc.contributor.author Goncales, F. L.
dc.contributor.author Guimaraes Pessoa, M.
dc.contributor.author Hezode, C.
dc.contributor.author Hindman, S. J.
dc.contributor.author Hofer, H.
dc.contributor.author Husa, P.
dc.contributor.author Idilman, R.
dc.contributor.author Kaberg, M.
dc.contributor.author Kaita, K. D. E.
dc.contributor.author Kautz, A.
dc.contributor.author Kaymakoglu, S.
dc.contributor.author Krajden, M.
dc.contributor.author Krarup, H.
dc.contributor.author Laleman, W.
dc.contributor.author Lavanchy, D.
dc.contributor.author Lazaro, P.
dc.contributor.author Marinho, R. T.
dc.contributor.author Marotta, P.
dc.contributor.author Mauss, S.
dc.contributor.author Mendes Correa, M. C.
dc.contributor.author Moreno, C.
dc.contributor.author Muellhaupt, B.
dc.contributor.author Myers, R. P.
dc.contributor.author Nemecek, V.
dc.contributor.author Ovrehus, A. L. H.
dc.contributor.author Parkes, J.
dc.contributor.author Peltekian, K. M.
dc.contributor.author Ramji, A.
dc.contributor.author Razavi, H.
dc.contributor.author Reis, N.
dc.contributor.author Roberts, S. K.
dc.contributor.author Roudot-Thoraval, F.
dc.contributor.author Ryder, S. D.
dc.contributor.author Sarmento-Castro, R.
dc.contributor.author Sarrazin, C.
dc.contributor.author Semela, D.
dc.contributor.author Sherman, M.
dc.contributor.author Shiha, G. E.
dc.contributor.author Sperl, J.
dc.contributor.author Starkel, P.
dc.contributor.author Stauber, R. E.
dc.contributor.author Thompson, A. J.
dc.contributor.author Urbanek, P.
dc.contributor.author Van Damme, P.
dc.contributor.author van Thiel, I.
dc.contributor.author Vandijck, D.
dc.contributor.author Vogel, W.
dc.contributor.author Waked, I.
dc.contributor.author Weis, N.
dc.contributor.author Wiegand, J.
dc.contributor.author Yosry, A.
dc.contributor.author Zekry, A.
dc.contributor.author Negro, F.
dc.contributor.author Sievert, W.
dc.contributor.author Gower, E.
dc.date.accessioned 2016-01-24T14:37:10Z
dc.date.available 2016-01-24T14:37:10Z
dc.date.issued 2014-05-01
dc.identifier http://dx.doi.org/10.1111/jvh.12249
dc.identifier.citation Journal of Viral Hepatitis. Hoboken: Wiley-Blackwell, v. 21, p. 60-89, 2014.
dc.identifier.issn 1352-0504
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37689
dc.description.abstract The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. the largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical. en
dc.description.sponsorship Gilead Sciences
dc.format.extent 60-89
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Viral Hepatitis
dc.rights Acesso aberto
dc.subject diagnosis en
dc.subject epidemiology en
dc.subject HCV en
dc.subject mortality en
dc.subject treatment en
dc.subject scenarios en
dc.subject prevalence en
dc.subject incidence en
dc.subject hepatitis C en
dc.subject disease burden en
dc.title Strategies to manage hepatitis C virus (HCV) disease burden en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Hannover Med Sch
dc.contributor.institution German Liver Fdn
dc.contributor.institution Orebro Univ Hosp
dc.contributor.institution Univ Orebro
dc.contributor.institution Hosp Valle de Hebron
dc.contributor.institution UCL
dc.contributor.institution Inst Clin & Expt Med
dc.contributor.institution Cairo Univ
dc.contributor.institution Ankara Univ
dc.contributor.institution Ghent Univ Hosp
dc.contributor.institution Wilhelminenspital Stadt Wien
dc.contributor.institution Ege Univ
dc.contributor.institution Karolinska Inst
dc.contributor.institution Karolinska Univ Hosp
dc.contributor.institution Univ Leipzig
dc.contributor.institution Osped Cantonale
dc.contributor.institution Univ Montreal
dc.contributor.institution Adv Tech Hlth Serv Res TAISS
dc.contributor.institution Fed Univ State Rio de Janeiro
dc.contributor.institution Arud Ctr Addict Med
dc.contributor.institution Hosp Santo Antonio Capuchos
dc.contributor.institution Hosp Puerta Hierro
dc.contributor.institution Univ Fed Rio Grande do Sul
dc.contributor.institution Odense Univ Hosp
dc.contributor.institution Region Hosp Hovedstaden
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institution Univ Plymouth
dc.contributor.institution Univ New S Wales
dc.contributor.institution Ain Shams Univ
dc.contributor.institution Dokuz Eylul Univ
dc.contributor.institution Ctr Dis Anal CDA
dc.contributor.institution Exigo Consultores
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Carlos III
dc.contributor.institution Univ Copenhagen
dc.contributor.institution Direccao Geral Saude
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Hop Henri Mondor
dc.contributor.institution Med Univ Vienna
dc.contributor.institution Masaryk Univ
dc.contributor.institution Univ Manitoba
dc.contributor.institution Hlth Sci Ctr
dc.contributor.institution European Liver Patients Assoc
dc.contributor.institution Istanbul Univ
dc.contributor.institution Univ British Columbia
dc.contributor.institution Aalborg Univ Hosp
dc.contributor.institution Katholieke Univ Leuven
dc.contributor.institution Univ Western Ontario
dc.contributor.institution Univ Dusseldorf
dc.contributor.institution Univ Libre Brussels
dc.contributor.institution Univ Zurich Hosp
dc.contributor.institution Univ Calgary
dc.contributor.institution Natl Inst Publ Hlth
dc.contributor.institution Univ Southhampton
dc.contributor.institution Dalhousie Univ & Hepatol Serv
dc.contributor.institution Assembleia Republ
dc.contributor.institution Alfred Hosp
dc.contributor.institution Monash Univ
dc.contributor.institution Nottingham Univ Hosp NHS Trust
dc.contributor.institution Biomed Res Unit
dc.contributor.institution Ctr Hosp Porto
dc.contributor.institution JW Goethe Univ Hosp
dc.contributor.institution Cantonal Hosp St Gallen
dc.contributor.institution Univ Toronto
dc.contributor.institution Egyptian Liver Res Inst & Hosp ELRIAH
dc.contributor.institution Catholic Univ Louvain
dc.contributor.institution Med Univ Graz
dc.contributor.institution St Vincents Hosp
dc.contributor.institution Univ Melbourne
dc.contributor.institution Charles Univ Prague
dc.contributor.institution Cent Mil Hosp
dc.contributor.institution Univ Antwerp
dc.contributor.institution Deutsch Leberhilfe eV
dc.contributor.institution Univ Ghent
dc.contributor.institution Hasselt Univ
dc.contributor.institution Med Univ Innsbruck
dc.contributor.institution Natl Liver Inst
dc.contributor.institution Copenhagen Univ Hosp
dc.contributor.institution Univ Hosp
dc.contributor.institution Monash Hlth
dc.description.affiliation Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
dc.description.affiliation German Liver Fdn, Hannover, Germany
dc.description.affiliation Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden
dc.description.affiliation Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden
dc.description.affiliation Hosp Valle de Hebron, CIBERehd, Barcelona, Spain
dc.description.affiliation UCL, Div Med, UCL Inst Liver & Digest Hlth, London, England
dc.description.affiliation Inst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic
dc.description.affiliation Cairo Univ, Cairo, Egypt
dc.description.affiliation Ankara Univ, TR-06100 Ankara, Turkey
dc.description.affiliation Ghent Univ Hosp, Ghent, Belgium
dc.description.affiliation Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria
dc.description.affiliation Ege Univ, Izmir, Turkey
dc.description.affiliation Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden
dc.description.affiliation Karolinska Univ Hosp, Dept Gastroenterol & Hepatol Infect Dis, Stockholm, Sweden
dc.description.affiliation Univ Leipzig, D-04109 Leipzig, Germany
dc.description.affiliation Osped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland
dc.description.affiliation Univ Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada
dc.description.affiliation Adv Tech Hlth Serv Res TAISS, Madrid, Spain
dc.description.affiliation Fed Univ State Rio de Janeiro, Dept Gastroenterol, Rio de Janeiro, Brazil
dc.description.affiliation Arud Ctr Addict Med, Zurich, Switzerland
dc.description.affiliation Hosp Santo Antonio Capuchos, Ctr Hosp Lisboa Cent, Dept Gastroenterol, Lisbon, Portugal
dc.description.affiliation Hosp Puerta Hierro, Madrid, Spain
dc.description.affiliation Univ Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil
dc.description.affiliation Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark
dc.description.affiliation Region Hosp Hovedstaden, Region Hovedstaden, Denmark
dc.description.affiliation Univ Fed Rio de Janeiro, Dept Clin Med, Rio de Janeiro, Brazil
dc.description.affiliation Univ Plymouth, Peninsula Sch Med & Dent, Plymouth PL4 8AA, Devon, England
dc.description.affiliation Univ New S Wales, Kirby Inst, Sydney, NSW, Australia
dc.description.affiliation Ain Shams Univ, Cairo, Egypt
dc.description.affiliation Dokuz Eylul Univ, Izmir, Turkey
dc.description.affiliation Ctr Dis Anal CDA, Louisville, CO USA
dc.description.affiliation Karolinska Inst, Dept Med Huddinge, Karolinska Univ Hosp, Infect Dis Unit, Stockholm, Sweden
dc.description.affiliation Exigo Consultores, Alhos Vedros, Portugal
dc.description.affiliation Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.affiliation Hosp Carlos III, CIBERehd, Madrid, Spain
dc.description.affiliation Univ Copenhagen, Copenhagen, Denmark
dc.description.affiliation Direccao Geral Saude, Lisbon, Portugal
dc.description.affiliation Univ Estadual Campinas, Fac Ciencias Med, Disciplina Doencas Infecciosas, Grp Estudo Hepatites,Dept Clin Med, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliation Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France
dc.description.affiliation Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria
dc.description.affiliation Masaryk Univ, Clin Infect Dis, Univ Hosp Brno, Brno, Czech Republic
dc.description.affiliation Ankara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey
dc.description.affiliation Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada
dc.description.affiliation Hlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada
dc.description.affiliation European Liver Patients Assoc, St Truiden, Belgium
dc.description.affiliation Istanbul Univ, Istanbul, Turkey
dc.description.affiliation Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada
dc.description.affiliation Aalborg Univ Hosp, Dept Med Gastroenterol, Aalborg, Denmark
dc.description.affiliation Aalborg Univ Hosp, Sect Mol Diagnost, Aalborg, Denmark
dc.description.affiliation Katholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium
dc.description.affiliation Univ Western Ontario, Div Gastroenterol, London, ON, Canada
dc.description.affiliation Univ Dusseldorf, Dusseldorf, Germany
dc.description.affiliation Univ São Paulo, Sch Med, São Paulo, Brazil
dc.description.affiliation Univ Libre Brussels, Erasme Univ Hosp, Brussels, Belgium
dc.description.affiliation Univ Zurich Hosp, Swiss HPB Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland
dc.description.affiliation Univ Zurich Hosp, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
dc.description.affiliation Univ Calgary, Div Gastroenterol & Hepatol, Liver Unit, Calgary, AB, Canada
dc.description.affiliation Natl Inst Publ Hlth, Natl Reference Lab Hepatitis, Prague, Czech Republic
dc.description.affiliation Univ Southhampton, Southampton, England
dc.description.affiliation Dalhousie Univ & Hepatol Serv, Queen Elizabeth II Hlth Sci Ctr, Capital Dist Hlth Author, Dept Med, Halifax, NS, Canada
dc.description.affiliation Dalhousie Univ & Hepatol Serv, Queen Elizabeth II Hlth Sci Ctr, Capital Dist Hlth Author, Dept Surg, Halifax, NS, Canada
dc.description.affiliation Univ British Columbia, Dept Gastroenterol, Vancouver, BC V5Z 1M9, Canada
dc.description.affiliation Assembleia Republ, Lisbon, Portugal
dc.description.affiliation Alfred Hosp, Melbourne, Vic, Australia
dc.description.affiliation Monash Univ, Melbourne, Vic 3004, Australia
dc.description.affiliation Hop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France
dc.description.affiliation Nottingham Univ Hosp NHS Trust, Nottingham, England
dc.description.affiliation Biomed Res Unit, Nottingham, England
dc.description.affiliation Ctr Hosp Porto, Dept Infect Dis, Oporto, Portugal
dc.description.affiliation JW Goethe Univ Hosp, Frankfurt, Germany
dc.description.affiliation Cantonal Hosp St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland
dc.description.affiliation Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada
dc.description.affiliation Egyptian Liver Res Inst & Hosp ELRIAH, Dakahliah, Egypt
dc.description.affiliation Catholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium
dc.description.affiliation Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, Graz, Austria
dc.description.affiliation St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia
dc.description.affiliation Univ Melbourne, Melbourne, Vic, Australia
dc.description.affiliation Charles Univ Prague, Dept Internal Med, Fac Med 1, Prague, Czech Republic
dc.description.affiliation Cent Mil Hosp, Prague, Czech Republic
dc.description.affiliation Univ Antwerp, B-2020 Antwerp, Belgium
dc.description.affiliation Deutsch Leberhilfe eV, Cologne, Germany
dc.description.affiliation Univ Ghent, Dept Hlth Econ & Patient Safety, B-9000 Ghent, Belgium
dc.description.affiliation Hasselt Univ, Diepenbeek, Belgium
dc.description.affiliation Med Univ Innsbruck, A-6020 Innsbruck, Austria
dc.description.affiliation Natl Liver Inst, Menoufia, Egypt
dc.description.affiliation Copenhagen Univ Hosp, Hvidovre, Denmark
dc.description.affiliation Univ New S Wales, St George Hosp Clin Sch Med, Sydney, NSW, Australia
dc.description.affiliation Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
dc.description.affiliation Univ Hosp, Div Gastroenterol & Hepatol, Geneva, Switzerland
dc.description.affiliation Univ Hosp, Div Clin Pathol, Geneva, Switzerland
dc.description.affiliation Monash Hlth, Melbourne, Vic, Australia
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.identifier.doi 10.1111/jvh.12249
dc.description.source Web of Science
dc.identifier.wos WOS:000333893200004



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