Author |
Moreira, Miriam A.
![]() Nascimento, Marcos A. ![]() Bozzo, Tatiana A. ![]() Cintra, Alvaro ![]() ![]() Silva, Sonia M. da ![]() ![]() Dalboni, Maria Aparecida ![]() ![]() Mouro, Margaret G. ![]() Higa, Elisa M. S. ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) |
Abstract | Background & aim: Oxidative stress has been implicated in the pathophysiology of many forms of acute renal failure. the aim was examine the effect of vitamin C on oxidative stress and its relationship with nitric oxide on gentamicin-induced nephrotoxicity in rats.Methods: We utilized 32 Wistar rats allocated in four groups of eight animals each: control (CTL), vitamin C (VIT C), gentamicin (GENTA), and GENTA + VIT C; all groups were treated during seven days.Results: Serum urea and creatinine, serum and renal tissue malondialdehyde, blood superoxide anion and hydrogen peroxide in GENTA were increased vs CTL and vs VIT C, and decreased in GENTA + VIT C vs GENTA (all P < 0.05). Serum nitric oxide increased in GENTA vs CTL and vs VIT C, and reduced in GENTA + VII C vs GENTA (P < 0.001). Urinary nitric oxide was reduced in GENTA vs CTL and vs VIT C and increased in GENTA + VIT C vs GENTA (P < 0.001). Severe degeneration of proximal tubules was present in GENTA, but only mild lesions were observed in GENTA + VIT C.Conclusion: This study suggests that VIT C is a valuable tool to protect against GENTA-induced nephrotoxicity, by reducing reactive oxygen species and increasing the nitric oxide. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Keywords |
Vitamin C
Gentamicin Acute renal failure Oxidative stress Nitric oxide |
Language | English |
Sponsor | FAP (Fundacao de Apoio a Universidade Federal de São Paulo) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
Date | 2014-04-01 |
Published in | Clinical Nutrition. Edinburgh: Churchill Livingstone, v. 33, n. 2, p. 296-301, 2014. |
ISSN | 0261-5614 (Sherpa/Romeo, impact factor) |
Publisher | Churchill Livingstone |
Extent | 296-301 |
Origin |
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Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:000334985500018 |
URI | http://repositorio.unifesp.br/handle/11600/37611 |
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