Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

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dc.contributor.author Candida, Thamyris
dc.contributor.author Franca, Jeronimo Pereira de
dc.contributor.author Fonseca Chaves, Alba Lucilvania
dc.contributor.author Rodrigues Lopes, Fernanda Andrade
dc.contributor.author Gaiba, Silvana
dc.contributor.author Sacramento, Celio Kersul do
dc.contributor.author Ferreira, Lydia Masako [UNIFESP]
dc.contributor.author Franca, Lucimar Pereira de
dc.date.accessioned 2016-01-24T14:34:58Z
dc.date.available 2016-01-24T14:34:58Z
dc.date.issued 2014-01-01
dc.identifier http://dx.doi.org/10.1590/S0102-86502014001400003
dc.identifier.citation Acta Cirurgica Brasileira. São Paulo: Acta Cirurgica Brasileira, v. 29, p. 10-14, 2014.
dc.identifier.issn 0102-8650
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37175
dc.description.abstract PURPOSE: To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS: Preparation ethanolic extract of the fruit of Morinda citrifolia L. Culture of melanoma cells B16-F10 for treatment with ethanolic extract of Morinda citrifolia L. fruit to determine cell viability by MTT and determination temporal effect of ethanolic extract fruit on the cell growth B16-F10 for 8 days. Evaluation of antimicrobial activity of ethanolic extract fruit against Staphylococcus aureus and Escherichia coli by determination of Minimum Inhibitory Concentration (MIC).RESULTS: the ethanolic extract of Morinda citrifolia L. fruit (10mg/mL) decreased cellular activity and inhibited 45% the rate of cell proliferation of B16-F10 melanoma treated during period studied. the ethanolic extract of Morinda citrifolia L. fruit demonstrated antimicrobial activity inhibiting the growth of both microorganisms studied. Staphylococcus aureus was less resistant to ethanolic extract of Morinda citrifolia L. fruit than Escherichia coli, 1 mg/mL and 10 mg/mL, respectively.CONCLUSION: What these results indicate that the ethanolic extract of the fruit of Morinda citrifolia L. showed antitumor activity with inhibition of viability and growth of B16-F10 cells and also showed antibacterial activity as induced inhibition of growth of Staphylococcus aureus and Escherichia coli. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Bahia Research Foundation (FAPESB)
dc.format.extent 10-14
dc.language.iso eng
dc.publisher Acta Cirurgica Brasileira
dc.relation.ispartof Acta Cirurgica Brasileira
dc.rights Acesso aberto
dc.subject Morinda citrifolia L. en
dc.subject Morinda en
dc.subject Drug Screening Assays Antitumor en
dc.subject Anti-Infective Agents en
dc.subject Antimicrobial en
dc.title Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil en
dc.type Artigo
dc.contributor.institution Univ Estadual Santa Cruz UESC
dc.contributor.institution Univ Estadual Santa Cruz
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution 1A CNPq
dc.contributor.institution Med III CAPES
dc.description.affiliation Univ Estadual Santa Cruz UESC, Dept Ciencias Biol, BR-45662900 Ilheus, BA, Brazil
dc.description.affiliation Univ Estadual Santa Cruz, Dept Agr & Environm Sci, BR-45662900 Ilheus, BA, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Plast Surg, São Paulo, Brazil
dc.description.affiliation 1A CNPq, São Paulo, Brazil
dc.description.affiliation Med III CAPES, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Plast Surg, São Paulo, Brazil
dc.identifier.scielo S0102-86502014001400003
dc.identifier.doi 10.1590/S0102-86502014001400003
dc.description.source Web of Science
dc.identifier.wos WOS:000342065300004



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