Author |
Assuncao Leme, Idaiane Batista
![]() ![]() Gadelha, Ary ![]() ![]() Sato, Joao Ricardo ![]() Ota, Vanessa Kiyomi ![]() ![]() Mari, Jair de Jesus ![]() ![]() Melaragno, Maria Isabel ![]() ![]() Cardoso Smith, Marilia de Arruda ![]() ![]() Nogueira Belangero, Sintia Iole ![]() ![]() Bressan, Rodrigo Affonseca ![]() ![]() Jackowski, Andrea Parolin ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) Universidade Federal do ABC (UFABC) |
Abstract | Objective Several studies have shown cortical volume loss in frontotemporal regions in schizophrenia patients, and it is known that these reductions may be associated with disease symptoms and cognitive deficits. the aim of this study was to investigate possible cortical thickness correlations in frontotemporal regions in relation to age at onset and duration of illness.Methods One hundred forty-eight schizophrenia patients (97 males; age and SD 36.30 +/- 10.06) and 87 (57 males; age and SD 36.48 +/- 10.10) age-matched healthy subjects underwent a brain MRI scan. Cortical segmentation and surface statistical analysis were performed using the FreeSurfer software package. Results were corrected for multiple comparisons using the Monte Carlo method considering a cluster-corrected Type I Error of 5%.Results Compared to controls, schizophrenia patients presented significant cortical thinning in the frontotemporal, parietal, and occipital cortices. No correlation between prefrontal cortex thickness and duration of illness in patients with schizophrenia or between frontotemporal cortical thickness and age at onset was found. However, a significant interaction between age and diagnosis was observed on frontal cortical thickness with patients presenting a thinner cortex than expected for age.Conclusion Although there was no correlation between age of onset and duration of illness with brain volume, our findings suggest that there is an accelerated cortical loss in schizophrenia, thus reinforcing the progressive processes of the disease. |
Keywords |
Age
age at onset cortical thickness duration of illness frontal lobe schizophrenia |
Language | English |
Sponsor | Roche Eli-Lilly |
Date | 2013-12-01 |
Published in | Cns Spectrums. New York: Cambridge Univ Press, v. 18, n. 6, p. 315-321, 2013. |
ISSN | 1092-8529 (Sherpa/Romeo, impact factor) |
Publisher | Cambridge Univ Press |
Extent | 315-321 |
Origin |
|
Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:000327777100005 |
URI | http://repositorio.unifesp.br/handle/11600/37050 |
File | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |