Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses

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dc.contributor.author Moriyama, Tais S. [UNIFESP]
dc.contributor.author Polanczyk, Guilherme V.
dc.contributor.author Terzi, Fernanda S.
dc.contributor.author Faria, Kauy M.
dc.contributor.author Rohde, Luis A.
dc.date.accessioned 2016-01-24T14:34:49Z
dc.date.available 2016-01-24T14:34:49Z
dc.date.issued 2013-12-01
dc.identifier http://dx.doi.org/10.1017/S109285291300031X
dc.identifier.citation Cns Spectrums. New York: Cambridge Univ Press, v. 18, n. 6, p. 296-306, 2013.
dc.identifier.issn 1092-8529
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37049
dc.description.abstract Objective/Introduction Attention-deficit/hyperactivity disorder (ADHD) in adult life is a prevalent condition. We systematically reviewed the literature available by searching for meta-analyses assessing pharmacological and psychosocial interventions for adults with ADHD.Methods Using wide-ranging search terms, we retrieved 191 titles from the PubMed and Cochrane databases. Two independent evaluators judged all abstracts. Only meta-analyses about the treatment of adults with ADHD were included. Information from meta-analyses found was systematically extracted by 3 independent evaluators.Results Eight meta-analyses were identified. Results from those meta-analyses suggest that stimulants are effective in decreasing ADHD symptoms on a short-term basis with a medium to large effect size (ES). Short-acting stimulants might be superior to long-acting stimulants, but no data on difference in adherence are available for the comparison of these two types of formulation. Bupropion is superior to placebo but less effective than stimulants. No conclusions about the impact of psychosocial interventions can be drawn based on meta-analyses so far.Discussion the efficacy of stimulants in reducing ADHD symptoms for adults is well documented in meta-analyses, but there is a concerning lack of meta-analysis about other treatment interventions.Conclusion the available meta-analytic literature does not cover questions of essential clinical relevance for adults with ADHD. en
dc.description.sponsorship Novartis
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Janssen-Cilag
dc.description.sponsorship Abbott
dc.description.sponsorship Eli-Lilly
dc.description.sponsorship Shire
dc.format.extent 296-306
dc.language.iso eng
dc.publisher Cambridge Univ Press
dc.relation.ispartof Cns Spectrums
dc.rights Acesso restrito
dc.subject ADHD en
dc.subject adults en
dc.subject inattention en
dc.subject stimulants en
dc.subject treatment en
dc.title Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses en
dc.type Resenha
dc.rights.license http://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.contributor.institution Natl Inst Dev Psychiat Children & Adolescents INC
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Univ Fed Rio Grande do Sul
dc.description.affiliation Natl Inst Dev Psychiat Children & Adolescents INC, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, São Paulo, Brazil
dc.description.affiliation Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1017/S109285291300031X
dc.description.source Web of Science
dc.identifier.wos WOS:000327777100003



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