AMPA receptors mediate passive avoidance deficits induced by sleep deprivation

AMPA receptors mediate passive avoidance deficits induced by sleep deprivation

Author Dubiela, Francisco Paulino Autor UNIFESP Google Scholar
Queiroz, Claudio Marcos Google Scholar
Moreira, Karin Di Monteiro Autor UNIFESP Google Scholar
Nobrega, Jose N. Google Scholar
Sita, Luciane Valeria Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Hipólide, Débora Cristina Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Norte
Ctr Addict & Mental Hlth
Universidade de São Paulo (USP)
Abstract The present study addressed the effects of sleep deprivation (SD) on AMPA receptor (AMPAR) binding in brain regions associated with learning and memory, and investigated whether treatment with drugs acting on AMPAR could prevent passive avoidance deficits in sleep deprived animals. [H-3]AMPA binding and GluR1 in situ hybridization signals were quantified in different brain regions of male Wistar rats either immediately after 96 h of sleep deprivation or after 24 h of sleep recovery following 96 h of sleep deprivation. Another group of animals were sleep deprived and then treated with either the AMPAR potentiator, aniracetam (25, 50 and 100 mg/kg, acute administration) or the AMPAR antagonist GYKI-52466 (5 and 10 mg/kg, acute and chronic administration) before passive avoidance training. Task performance was evaluated 2 h and 24 h after training. A significant reduction in [H-3]AMPA binding was found in the hippocampal formation of SD animals, while no alterations were observed in GluR1 mRNA levels. the highest dose of aniracetam (100 mg/kg) reverted SD-induced impairment of passive avoidance performance in both retention tests, whereas GYKI-52466 treatment had no effect. Pharmacological enhancement of AMPAR function may revert hippocampal-dependent learning impairments produced after SD. We argue that such effects might be associated with reduced AMPAR binding in the hippocampus of sleep deprived animals. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Sleep deprivation
AMPA receptor
Passive avoidance task
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Associacao Fundo de Incentivo a Pesquisa
Grant number FAPESP: 1998/1403-3
FAPESP: 2007/53176-8
FAPESP: 2011/09816-8
Date 2013-11-15
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 257, p. 189-196, 2013.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 189-196
Access rights Closed access
Type Article
Web of Science ID WOS:000328519200024

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