Challenges in the Therapy of Chromoblastomycosis

Challenges in the Therapy of Chromoblastomycosis

Author Queiroz-Telles, Flavio Google Scholar
Santos, Daniel Wagner de C. L. Autor UNIFESP Google Scholar
Institution Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Inst Infect Dis Emilio Ribas
Abstract Chromoblastomycosis (CBM) is an implantation mycosis mainly occurring in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long-term therapy with systemic antifungals flanked by various physical treatment regimens. As in other neglected endemic mycoses, comparative clinical trials have not been performed for this disease; nowadays, therapy is mainly based on a few open trials and on expert opinions. Itraconazole, either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been employed successfully in combination with antifungals in patients presenting with CBM. in the present paper, the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.
Keywords Implantation mycoses
Subcutaneous mycoses
Chromomycosis
Black fungi
Melanized fungi
Dematiaceous
Fonsecaea sp.
Cladophialophora sp.
Verrucous
Muriform
Sclerotic
Antifungals
Itraconazole
Posaconazole
Terbinafine
Photodynamic therapy
Language English
Date 2013-06-01
Published in Mycopathologia. Dordrecht: Springer, v. 175, n. 5-6, p. 477-488, 2013.
ISSN 0301-486X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 477-488
Origin http://dx.doi.org/10.1007/s11046-013-9648-x
Access rights Closed access
Type Article
Web of Science ID WOS:000319768900013
URI http://repositorio.unifesp.br/handle/11600/36384

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