Acute mood effect of donepezil in young, healthy volunteers

Acute mood effect of donepezil in young, healthy volunteers

Author Pompeia, Sabine Autor UNIFESP Google Scholar
Gouveia, Juliana Ramos Autor UNIFESP Google Scholar
Fernandes Galduroz, Jose Carlos Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective Chronic use of the acetylcholinesterase inhibitor donepezil has been found to improve mood or to induce mania/hypomania in many neuropsychiatric patients with altered cholinergic and dopaminergic tone. Our aim was to determine whether acutely administered donepezil would alter mood in volunteers with no such alterations. Methods This investigation was a double-blind, crossover design study of 15 young, healthy male participants who were allocated in random order to three oral treatments: placebo and 5-mg and 7.5-mg donepezil (doses which exert clinical and acute cognitive effects without considerable peripheral side effects). At the theoretical peak-plasma concentrations of donepezil, volunteers rated how they felt on validated questionnaires, which included various dimensions of subjective feelings. We also assessed changes in brain-derived neurotrophic factor (BDNF), which is increased by donepezil after chronic regimes and is related to modulation of mood. Results Donepezil significantly increased ratings of vigour and anxiety symptoms (medium effect sizes). No changes in bodily symptoms or BDNF were observed. Conclusions Acute donepezil administration in participants with unaltered cholinergic and dopaminergic tone led to positive and negative changes in affect. These results call for further research on the direct mood effects of donepezil. Copyright (c) 2013 John Wiley & Sons, Ltd.
Keywords donepezil
mood
affect
brain-derived neurotrophic factor
acetylcholine
dopamine
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2010/08840-0
Date 2013-05-01
Published in Human Psychopharmacology-clinical and Experimental. Hoboken: Wiley-Blackwell, v. 28, n. 3, p. 263-269, 2013.
ISSN 0885-6222 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 263-269
Origin http://dx.doi.org/10.1002/hup.2319
Access rights Closed access
Type Article
Web of Science ID WOS:000319418600009
URI http://repositorio.unifesp.br/handle/11600/36265

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