Is there a role for curcumin in the treatment of bipolar disorder?

Is there a role for curcumin in the treatment of bipolar disorder?

Author Brietzke, Elisa Autor UNIFESP Google Scholar
Mansur, Rodrigo Barbachan Autor UNIFESP Google Scholar
Zugman, André Autor UNIFESP Google Scholar
Carvalho, André Férrer Google Scholar
Macedo, Danielle Silveira Google Scholar
Cha, Danielle S. Google Scholar
Abílio, Vanessa Costhek Autor UNIFESP Google Scholar
McIntyre, Roger S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Ceara
Univ Toronto
Abstract Curcumin is a polyphenolic nonflavonoid compound extracted from the rhizome of turmeric (Curcuma longa), a plant commonly used in Indian and Chinese traditional medicine to treat rheumatism, cough, inflammation and wounds. Curcumin putative targets, known based on studies of diverse central nervous system disorders other than bipolar disorders (BD) include several proteins currently implicated in the pathophysiology of BD. These targets include, but are not limited to, transcription factors activated by environmental stressors and pro-inflammatory cytoldnes, protein kinases (PICA, PKC), enzymes, growth factors, inflammatory mediators, and anti-apoptotic proteins (Bcl-XL). Herein, we review previous studies on the anti-inflammatory and anti-oxidant properties of curcumin and discuss its therapeutic potential in BD. (C) 2013 Elsevier B.V. All rights reserved.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-05-01
Published in Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 80, n. 5, p. 606-612, 2013.
ISSN 0306-9877 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 606-612
Origin http://dx.doi.org/10.1016/j.mehy.2013.02.001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000317995000022
URI http://repositorio.unifesp.br/handle/11600/36230

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