Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

Author Balsalobre, Leonardo Autor UNIFESP Google Scholar
Pezato, Rogerio Autor UNIFESP Google Scholar
Perez-Novo, Claudina Google Scholar
Alves, Maria Teresa S. Autor UNIFESP Google Scholar
Santos, Rodrigo P. Autor UNIFESP Google Scholar
Bachert, Claus Google Scholar
Weckx, Luc L. M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Ghent
Abstract Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.
Keywords TGF-beta 1
Nasal polyps
Rhinosinusitis
Mucosa
Language English
Date 2013-04-15
Published in Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
ISSN 1916-0216 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 5
Origin http://dx.doi.org/10.1186/1916-0216-42-29
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000318410400001
URI http://repositorio.unifesp.br/handle/11600/36209

Show full item record




File

Name: WOS000318410400001.pdf
Size: 3.160Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account