A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis

Author Ventura, Janaina Souza Autor UNIFESP Google Scholar
Faria, Fernanda Google Scholar
Correia Batista, Isabel Fatima Google Scholar
Simons, Simone Michaela Autor UNIFESP Google Scholar
Lourenco Oliveira, Daniella Gorete Autor UNIFESP Google Scholar
Morais, Katia L. P. Autor UNIFESP Google Scholar
Chudzinski-Tavassi, Ana Marisa Autor UNIFESP Google Scholar
Institution Inst Butantan
Universidade Federal de São Paulo (UNIFESP)
Abstract Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. in this study was demonstrated that the Amblyomin-X (which is a recombinant protein that exerts similarity to the Kunitz-type inhibitors and shows pro-apoptotic effects in different tumor cell lines) and heparin (a classic anticoagulant) have similar effects on cancer progression and on normalization of the hypercoagulable state. However, Amblyomin-X showed a distinct mechanism in triggering its effects in vitro, because it exerted a cytotoxic effect in cancer cells by inducing apoptosis and promoting cell cycle arrest. (C) 2013 Elsevier Masson SAS. All rights reserved.
Keywords Amblyomin-X
Heparin
Antitumor
Apoptosis
Coagulation
Cell cycle
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CAT/CEPID
FINEP
Date 2013-04-01
Published in Biomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 67, n. 3, p. 192-196, 2013.
ISSN 0753-3322 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 192-196
Origin http://dx.doi.org/10.1016/j.biopha.2012.11.009
Access rights Closed access
Type Article
Web of Science ID WOS:000317098900002
URI http://repositorio.unifesp.br/handle/11600/36156

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