Chemical Composition and Antimicrobial Activity of Essential Oils from Chromolaena laevigata during Flowering and Fruiting Stages

Chemical Composition and Antimicrobial Activity of Essential Oils from Chromolaena laevigata during Flowering and Fruiting Stages

Author Murakami, Cynthia Google Scholar
Lago, Joao H. G. Autor UNIFESP Google Scholar
Perazzo, Fabio F. Autor UNIFESP Google Scholar
Ferreira, Karen S. Autor UNIFESP Google Scholar
Lima, Marcos E. L. Google Scholar
Moreno, Paulo R. H. Google Scholar
Young, Maria C. M. Google Scholar
Institution Inst Bot
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The chemical compositions and antimicrobial activities of essential oils from the leaves, stems, capitula, and cypselas of Chromolaena laevigata were evaluated at two different phenological stages, flowering and fruiting. Thirty-eight compounds were identified in the crude oils by GC/MS. the sesquiterpene laevigatin was the major constituent of the leaf, capitulum, and cypsela oils, while the sesquiterpene spathulenol was the main component in the stem oils. the antimicrobial activities of the oils were evaluated against Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Stem oil obtained from Chromolaena laevigata during the fruiting stage generally showed the highest activity with minimum inhibitory concentration (MIC) values of 62.5g/ml against Candida albicans and S. aureus, and 500g/ml against P. aeruginosa and E. coli. Pure laevigatin exhibited MIC values of 500 and 125g/ml against C. albicans and S. aureus, respectively, indicating that this constituent could be responsible, at least in part, for the antimicrobial activities detected in the crude oils. More studies concerning the biological activities of isolated derivatives are required to improve our knowledge of the antimicrobial potential of volatile compounds present in native plants.
Keywords Chromolaena laevigata
Essential oils
Laevigatin
Antimicrobial activity
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-04-01
Published in Chemistry & Biodiversity. Weinheim: Wiley-v C H Verlag Gmbh, v. 10, n. 4, p. 621-627, 2013.
ISSN 1612-1872 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 621-627
Origin http://dx.doi.org/10.1002/cbdv.201200025
Access rights Closed access
Type Article
Web of Science ID WOS:000317616400011
URI http://repositorio.unifesp.br/handle/11600/36136

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