Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

Author Pezato, Rogerio Autor UNIFESP Google Scholar
Balsalobre, Leonardo Autor UNIFESP Google Scholar
Lima, Milena Google Scholar
Bezerra, Thiago F. P. Google Scholar
Voegels, Richard L. Google Scholar
Gregório, Luis Carlos Autor UNIFESP Google Scholar
Stamm, Aldo Cassol Autor UNIFESP Google Scholar
van Zele, Thibaut Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Ghent
Mil Police Hosp
Universidade de São Paulo (USP)
Abstract This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus.These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
Keywords Airway remodeling
Superantigens
Nasal polyps
Language English
Date 2013-03-28
Published in Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
ISSN 1916-0216 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 5
Origin http://dx.doi.org/10.1186/1916-0216-42-27
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000318410000002
URI http://repositorio.unifesp.br/handle/11600/36104

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