DRD1 rs4532 polymorphism: A potential pharmacogenomic marker for treatment response to antipsychotic drugs

DRD1 rs4532 polymorphism: A potential pharmacogenomic marker for treatment response to antipsychotic drugs

Autor Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Spindola, Leticia Nery Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Santos Filho, Airton Ferreira dos Autor UNIFESP Google Scholar
Santoro, Marcos Leite Autor UNIFESP Google Scholar
Christofolini, Denise Maria Google Scholar
Bellucco, Fernanda Teixeira Autor UNIFESP Google Scholar
Ribeiro-dos-Santos, Andrea Kely Google Scholar
Santos, Sidney Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Melaragno, Maria Isabel Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC FMABC
Universidade Federal do Pará (UFPA)
Resumo We investigated the association of dopamine receptor D1 gene (DRD1) rs4532 polymorphism with antipsychotic treatment response in schizophrenia. We have analyzed 124 patients with schizophrenia, consisting of 59 treatment resistant (TR) and 65 non-TR. We found an association between G-allele and TR schizophrenia (p=0.001; adjusted OR=2.71). Setting the common AA-genotype as reference, the GG-homozygous presented a five-fold risk compared to AA-homozygous (p=0.010; OR=5.56) with an intermediate result for AG-genotype (p=0.030; adjusted OR=2.64). the DRD1 rs4532 polymorphism showed a dose-response gradient with increased risk for treatment resistance and may be a potential pharmacogenetic marker for antipsychotic drug treatment response. (C) 2012 Elsevier B.V. All rights reserved.
Assunto Schizophrenia
DRD1
Pharmacogenomics
Treatment-resistant
Antipsycotic
Dopamine
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: FAPESP 2007/58736-1
FAPESP: 2011/00030-1
Data 2012-12-01
Publicado em Schizophrenia Research. Amsterdam: Elsevier B.V., v. 142, n. 1-3, p. 206-208, 2012.
ISSN 0920-9964 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 206-208
Fonte http://dx.doi.org/10.1016/j.schres.2012.08.003
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000311220900031
URI http://repositorio.unifesp.br/handle/11600/35574

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