Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients

Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients

Author Alvarenga, Pedro G. Google Scholar
Rosario, Maria C. do Autor UNIFESP Google Scholar
Batistuzzo, Marcelo C. Google Scholar
Diniz, Juliana B. Google Scholar
Shavitt, Roseli G. Google Scholar
Duran, Fabio L. S. Google Scholar
Dougherty, Darin D. Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Miguel, Euripedes C. Google Scholar
Hoexter, Marcelo Q. Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Harvard Univ
Abstract Background: Clinical and sociodemographic findings have supported that OCD is heterogeneous and composed of multiple potentially overlapping and stable symptom dimensions. Previous neuroimaging investigations have correlated different patterns of OCD dimension scores and gray matter (GM) volumes. Despite their relevant contribution, some methodological limitations, such as patient's previous medication intake, may have contributed to inconsistent findings.Method: Voxel-based morphometry was used to investigate correlations between regional GM volumes and symptom dimensions severity scores in a sample of 38 treatment-naive OCD patients. Several standardized instruments were applied, including an interview exclusively developed for assessing symptom dimensions severity (DY-BOCS).Results: Scores on the aggression dimension were positively correlated with GM volumes in lateral parietal cortex in both hemispheres and negatively correlated with bilateral insula, left putamen and left inferior OFC. Scores on the sexual/religious dimension were positively correlated with GM volumes within the right middle lateral OFC and right DLPFC and negatively correlated with bilateral ACC. Scores on the hoarding dimension were positively correlated with GM volumes in the left superior lateral OFC and negatively correlated in the right parahippocampal gyrus. No significant correlations between GM volumes and the contamination or symmetry dimensions were found.Conclusions: Building upon preexisting findings, our data with treatment-naive OCD patients have demonstrated distinct GM substrates implicated in both cognitive and emotion processing across different OCS dimensions. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Obsessive-compulsive disorder (OCD)
Symptom dimensions
Neuroimaging
Voxel-based morphometry (VBM)
Treatment-naive
Gray matter (GM)
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Astra Zeneca
Bristol
Janssen
Lundbeck
Eli Lilly
Novartis
Roche
Grant number FAPESP: 2005/55628-8
FAPESP: 06/61459-7
FAPESP: 06/50273-0
FAPESP: 2005/04206-6
CAPES: 4375/08-4
Date 2012-12-01
Published in Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 46, n. 12, p. 1635-1642, 2012.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1635-1642
Origin http://dx.doi.org/10.1016/j.jpsychires.2012.09.002
Access rights Closed access
Type Article
Web of Science ID WOS:000311983100016
URI http://repositorio.unifesp.br/handle/11600/35566

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