Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents

Reduction in the Leptin Concentration as a Predictor of Improvement in Lung Function in Obese Adolescents

Author Silva, Patricia Leão Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Cheik, Nadia Carla Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Inoue, Daniela Sayuri Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
Abstract Objective: To assess the effects of weight loss on adipokines, asthma-related symptoms, exercise-induced bronchospasm (EIB) and lung function, and to evaluate the role of leptin and adiponectin levels on lung function after treatment in obese adolescents. Methods: 84 postpubertal obese adolescents were enrolled and distributed in quartiles according to weight loss (low (<2.5 kg), low to moderate (>2.5 and <8 kg), moderate (<8 and <14 kg) and massive (<14 kg)). Body composition was measured by plethysmography, and visceral and subcutaneous fat were detected by ultrasound. Serum levels of adiponectin and leptin were analyzed. Lung function, asthma and EIB were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1 year of interdisciplinary intervention consisting of physiotherapy, medical, nutritional, exercise, and psychological therapy. Results: After treatment the moderate and massive weight loss promoted an increase in adiponectin and adiponectin/leptin (A/L) ratio as well as a decrease in leptin levels and a reduction in EIB frequency and asthma-related symptoms. Furthermore, the reduction in leptin levels was a predictor factor to improvement in lung function. Conclusion: Interdisciplinary therapy was able to decrease EIB and asthma-related symptoms and to improve pro/anti-inflammatory adipokines. Additionally, the leptin concentration was a predictor factor to explain changes in lung function. Copyright (C) 2012 S. Karger AG, Basel
Keywords Obesity management
Adolescent
Adipokines
Lung function
Language English
Sponsor AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CENESP
FADA
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
UNIFESP
Grant number FAPESP: 2008/53069-0
FAPESP: 2006/00684-3
FAPESP: 98/14303-3
FAPEMIG: APQ-01102-09
Date 2012-12-01
Published in Obesity Facts. Basel: Karger, v. 5, n. 6, p. 806-820, 2012.
ISSN 1662-4025 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 806-820
Origin http://dx.doi.org/10.1159/000345840
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000315772300002
URI http://repositorio.unifesp.br/handle/11600/35530

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