Hair Cortisol and Stressful Life Events Retrospective Assessment in Crack Cocaine Users

Hair Cortisol and Stressful Life Events Retrospective Assessment in Crack Cocaine Users

Author Grassi-Oliveira, Rodrigo Google Scholar
Pezzi, Julio Carlos Google Scholar
Daruy-Filho, Ledo Google Scholar
Viola, Thiago Wendt Google Scholar
Francke, Ingrid D' Avila Google Scholar
Leite, Carlos Eduardo Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Institution Pontifical Catholic Univ Rio Grande Sul PUCRS
UFCSPA
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Some evidence suggests that altered hypothalamic-pituitary-adrenal (HPA) axis functioning in cocaine users might play a role in the pathophysiology of substance abuse. This study aimed to investigate the relationship between exposure to negative life events and cortisol hair concentrations in crack cocaine users during the 3 months prior to admission to a detoxification program. Methods: A total of 23 treatment-seeking, crack cocaine-dependent women were selected for this study 1 week after admission to an inpatient treatment at a locked treatment facility. the Paykel Life Events Scale measured the occurrence of stressful life events 3 months before admission. Hair cortisol concentration was measured during these three previous months. Results: the partial correlations, using severity of dependence as control variable, revealed that there is a positive association between hair cortisol concentration and the number of negative life events exposure 90 days (r = .56; p = .007) and 30 days (r = .42; p = .048) prior to admission at the hospital. One-way ANOVA suggests that hair cortisol levels and stress load significantly increase over 3 months prior to hospitalization. Conclusions: the results of this study indicate that there is a positive association between measures of long-term cumulative cortisol secretion and the number of stressful events reported by women receiving inpatient treatment for crack cocaine dependence. Therefore, this study suggests that stress load can be objectively quantified and noninvasively assessed. Scientific Significance: This study is the first to investigate HPA axis functioning using hair cortisol concentrations among crack cocaine-dependent users. It is a promising strategy to assess stress load in substance abusers.
Keywords HPA axis
neuroendocrine
stress
substance abuse
hospitalization
assessment
Language English
Date 2012-11-01
Published in American Journal of Drug and Alcohol Abuse. London: Informa Healthcare, v. 38, n. 6, p. 535-538, 2012.
ISSN 0095-2990 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 535-538
Origin http://dx.doi.org/10.3109/00952990.2012.694538
Access rights Closed access
Type Article
Web of Science ID WOS:000309667200004
URI http://repositorio.unifesp.br/handle/11600/35493

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