Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [Tc-99m]TRODAT-1

Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [Tc-99m]TRODAT-1

Author Hoexter, Marcelo Q. Autor UNIFESP Google Scholar
Fadel, Gustavo Autor UNIFESP Google Scholar
Felicio, Andre C. Autor UNIFESP Google Scholar
Calzavara, Mariana B. Autor UNIFESP Google Scholar
Batista, Ilza R. Autor UNIFESP Google Scholar
Reis, Marilia A. Autor UNIFESP Google Scholar
Shih, Ming C. Autor UNIFESP Google Scholar
Pitman, Roger K. Google Scholar
Andreoli, Sergio B. Autor UNIFESP Google Scholar
Mello, Marcelo F. Autor UNIFESP Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Harvard Univ
Abstract Some evidence suggests a hyperdopaminergic state in posttraumatic stress disorder (PTSD). the 9-repetition allele (9R) located in the 3' untranslated region of the dopamine transporter (DAT) gene (SLC6A3) is more frequent among PTSD patients. in vivo molecular imaging studies have shown that healthy 9R carriers have increased striatal DAT binding. However, no prior study evaluated in vivo striatal DAT density in PTSD.The objective of this study was to evaluate in vivo striatal DAT density in PTSD.Twenty-one PTSD subjects and 21 control subjects, who were traumatized but asymptomatic, closely matched comparison subjects evaluated with the Clinician-Administered PTSD Scale underwent a single-photon emission computed tomography scan with [(TC)-T-99m]-TRODAT-1. DAT binding potential (DAT-BP) was calculated using the striatum as the region of the interest and the occipital cortex as a reference region.PTSD patients had greater bilateral striatal DAT-BP (mean +/- SD; left, 1.80 +/- 0.42; right, 1.78 +/- 0.40) than traumatized control subjects (left, 1.62 +/- 0.32; right, 1.61 +/- 0.31; p = 0.039 for the left striatum and p = 0.032 for the right striatum).These results provide the first in vivo evidence for increased DAT density in PTSD. Increases in DAT density may reflect higher dopamine turnover in PTSD, which could contribute to the perpetuation and potentiation of exaggerated fear responses to a given event associated with the traumatic experience. Situations that resemble the traumatic event turn to be interpreted as highly salient (driving attention, arousal, and motivation) in detriment of other daily situations.
Keywords Posttraumatic stress disorder
Depression
Corpus striatum
Dopamine transporter
Single-photon emission computed tomography
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Instituto do Cerebro, Instituto de Ensino e Pesquisa do Hospital Israelita Albert Einstein
Astra Zeneca
Bristol
Janssen
Lundbeck
Eli Lilly
Novartis
Roche
Grant number FAPESP: 2004/15039-0
Instituto do Cerebro, Instituto de Ensino e Pesquisa do Hospital Israelita Albert Einstein: 148-06
Date 2012-11-01
Published in Psychopharmacology. New York: Springer, v. 224, n. 2, p. 337-345, 2012.
ISSN 0033-3158 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 337-345
Origin http://dx.doi.org/10.1007/s00213-012-2755-4
Access rights Closed access
Type Article
Web of Science ID WOS:000310321400011
URI http://repositorio.unifesp.br/handle/11600/35450

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