Addition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPD

Addition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPD

Author Canto, Nívea Dias do Google Scholar
Ribeiro, Jorge Pinto Google Scholar
Neder, José Alberto Autor UNIFESP Google Scholar
Chiappa, Gaspar Rogério da Google Scholar
Institution Hosp Clin Porto Alegre
Univ So Santa Catarina
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the addition of tiotropium bromide (110) to formoterol fumarate (FOR) improves exercise performance in patients with chronic obstructive pulmonary disease (COPD). in this study, we test the hypothesis that the addition of TIO to for may improve respiratory muscle performance and oxygen uptake kinetics after exercise in patients with COPD.Methods: Thirty eight patients with COPD were randomized to a 2 week treatment with for 12 mu g twice a day plus TIO 18 mu g once a day (FOR + TIO) or for 12 mu g twice a day plus placebo (FOR + PLA) once a day, using a double-blind crossover design. Inspiratory muscle. Strength was measured before, immediately after, as well as 2, 5, and 10 min during recovery of exercise. Time to limit of tolerance on a constant work load exercise test and oxygen uptake kinetics during recovery were evaluated before and after intervention.Results: Only for + TIO improved resting (63 +/- 10 cm to 84 +/- 11 cmH(2)O) and post-exercise (49 +/- 7 cm to 84 +/- 11 cmH(2)O) maximal inspiratory pressure. Time to limit of tolerance on the constant work load test was increased by for + PLA and by for + TIO, but the size of the increment was significantly larger with for + TIO (40.7 +/- 7.6% vs. 84.5 +/- 8.2%; p < 0.05). Only for + TIO improved oxygen uptake kinetics during recovery (69 +/- 21 to 60 +/- 18s). the improvement in maximal inspiratory pressure (0.78, p < 0.001) and in oxygen uptake kinetics (-0.91, p < 0.001) correlated with the change in time to the limit of tolerance.Conclusions: the addition of TIO to for improves inspiratory muscle strength and oxygen uptake kinetics after exercise in COPD patients. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Respiratory muscles
Oxygen
Inspiratory muscle strength
Constant work test
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2012-10-01
Published in Respiratory Medicine. London: W B Saunders Co Ltd, v. 106, n. 10, p. 1404-1412, 2012.
ISSN 0954-6111 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 1404-1412
Origin http://dx.doi.org/10.1016/j.rmed.2012.05.012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000309147400008
URI http://repositorio.unifesp.br/handle/11600/35301

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