Accuracy of anthropometric measurements in estimating fat mass in individuals with 21-hydroxylase deficiency

Accuracy of anthropometric measurements in estimating fat mass in individuals with 21-hydroxylase deficiency

Author Gonçalves, Ezequiel Moreira Google Scholar
Silva, Analiza Mónica Google Scholar
Santos, Diana A. Google Scholar
Lemos-Marini, Sofia Helena Valente de Google Scholar
Santos, Allan de Oliveira Google Scholar
Santos, Carolina Taddeo Mendes dos Google Scholar
Mello, Maricilda Palandi de Autor UNIFESP Google Scholar
Guerra-Junior, Gil Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Univ Tecn Lisboa
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the use of anthropometric measurements to estimate the percentage of body fat (%BF) is easy and inexpensive. However, the accuracy of these methods in patients with 21-hydroxylase deficiency (21OHD) has not been explored. the objective of this study was to evaluate the accuracy of skinfold-based models, body mass index (BMI), and waist circumference (WC) in estimations of %BF using dual-energy X-ray absorptiometry (DXA) as the reference method in individuals with 21OHD.Methods: Fifty-four 21OHD patients (32 women and 22 men), aged 7 to 20 y, were recruited for the study. DXA was used to determine %BF; four predictive skinfold equations, BMI, and WC were assessed for accuracy in determining %BF.Results: All predictive skinfold equations were highly associated (R, range: 0.82-0.89) with DXA %BF values. in women, BMI and WC showed moderate correlations (R = 0.69 for both BMI and WC) with DXA values. in contrast, among men there was a low explanatory power for BMI (13%) and WC (4%) and high errors (BMI, 6.9%; WC, 7.4%). All predictive equations significantly underestimated %BF (range of differences, -4.1 to -8.9) compared with DXA (women, 31.3 +/- 6.1; men, 24.4 +/- 7.3), and large limits of agreement were observed (range, -15.3 to 1.7 and -15.5 to 4.2 for women and men, respectively).Conclusion: in children and adolescents with 21OHD, %BF as estimated by skinfold measurements was associated more strongly with DXA-assessed %BF than both BMI and WC. However, still, the skinfold-based assessment underestimated DXA %BF and showed moderate agreement (C) 2012 Elsevier Inc. All rights reserved.
Keywords Anthropometry
Congenital adrenal hyperplasia
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CAPES: BEX 2018/10-1
Date 2012-10-01
Published in Nutrition. New York: Elsevier B.V., v. 28, n. 10, p. 984-990, 2012.
ISSN 0899-9007 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 984-990
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000309319600006

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