The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study

The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study

Author Montes de Oca, Maria Google Scholar
Halbert, Ronald J. Google Scholar
Victorina Lopez, Maria Google Scholar
Perez-Padilla, Rogelio Google Scholar
Talamo, Carlos Google Scholar
Moreno, Dolores Google Scholar
Muino, Adrianna Google Scholar
Jardim, Jose Roberto Autor UNIFESP Google Scholar
Valdivia, Gonzalo Google Scholar
Pertuze, Julio Google Scholar
Menezes, Ana Maria B. Google Scholar
Institution Cent Univ Venezuela
UCLA Sch Publ Hlth
Univ Republica
Inst Resp Dis
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Pelotas
Pontificia Univ Catolica Chile
Abstract Little information exists regarding the epidemiology of the chronic bronchitis phenotype in unselected chronic obstructive pulmonary disease (COPD) populations. We examined the prevalence of the chronic bronchitis phenotype in COPD and non-COPD subjects from the PLATINO study, and investigated how it is associated with important outcomes.Post-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.70 was used to define COPD. Chronic bronchitis was defined as phlegm on most days, at least 3 months per year for >= 2 yrs. We also analysed another definition: cough and phlegm on most days, at least 3 months per year for >= 2 yrs.Spirometry was performed in 5,314 subjects (759 with and 4,554 without COPD). the proportion of subjects with and without COPD with chronic bronchitis defined as phlegm on most days, at least 3 months per year for >= 2 yrs was 14.4 and 6.2%, respectively. Using the other definition the prevalence was lower: 7.4% with and 2.5% without COPD. Among subjects with COPD, those with chronic bronchitis had worse lung function and general health status, and had more respiratory symptoms, physical activity limitation and exacerbations.Our study helps to understand the prevalence of the chronic bronchitis phenotype in an unselected COPD population at a particular time-point and suggests that chronic bronchitis in COPD is possibly associated with worse outcomes.
Keywords Asthma
chronic cough
chronic obstructive pulmonary disease
epidemiology
Language English
Sponsor Boehringer Ingelheim GmbH
Asociacion Latinoamericana de Torax
Date 2012-07-01
Published in European Respiratory Journal. Sheffield: European Respiratory Soc Journals Ltd, v. 40, n. 1, p. 28-36, 2012.
ISSN 0903-1936 (Sherpa/Romeo, impact factor)
Publisher European Respiratory Soc Journals Ltd
Extent 28-36
Origin http://dx.doi.org/10.1183/09031936.00141611
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000307287500008
URI http://repositorio.unifesp.br/handle/11600/35023

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