Use of beta-blockers for the treatment of cardiac arrest due to ventricular fibrillation/pulseless ventricular tachycardia: A systematic review

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dc.contributor.author Oliveira, Felipe Carvalho de
dc.contributor.author Feitosa-Filho, Gilson Soares
dc.contributor.author Fonteles Ritt, Luiz Eduardo [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:20Z
dc.date.available 2016-01-24T14:27:20Z
dc.date.issued 2012-06-01
dc.identifier http://dx.doi.org/10.1016/j.resuscitation.2012.01.025
dc.identifier.citation Resuscitation. Clare: Elsevier B.V., v. 83, n. 6, p. 674-683, 2012.
dc.identifier.issn 0300-9572
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34962
dc.description.abstract Introduction: Advanced Life Support guidelines recommend the use of epinephrine during Cardiopulmonary Resuscitation (CPR), as to increase coronary blood flow and perfusion pressure through its alpha-adrenergic peripheral vasoconstriction, allowing minimal rises in coronary perfusion pressure to make defibrillation possible. Contrasting to these alpha-adrenergic effects, epinephrine's beta-stimulation may have deleterious effects through an increase in myocardial oxygen consumption and a reduction of subendocardial perfusion, leading to postresuscitation cardiac dysfunction.Objective: the present paper consists of a systematic review of the literature regarding the use of beta-blockade in cardiac arrest due to ventricular fibrillation (VF) and pulseless ventricular tachycardia (VT).Methods: Studies were identified through MEDLINE electronic databases research and were included those regarding the use of beta-blockade during CPR.Results: Beta-blockade has been extensively studied in animal models of CPR. These studies not only suggest that beta-blockade could reduce myocardial oxygen requirements and the number of shocks necessary for defibrillation, but also improve postresuscitation myocardial function, diminish arrhythmia recurrences and prolong survival. A few case reports described successful beta-blockade use in patients, along with two prospective human studies, suggesting that it could be safe and effectively used during cardiac arrest in humans.Conclusion: Even though the existing literature points toward a beneficial effect of beta-blockade in patients presenting with cardiac arrest due to VF/pulseless VT, high quality human trials are still lacking to answer this question definitely. (C) 2012 Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 674-683
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Resuscitation
dc.rights Acesso restrito
dc.subject Cardiopulmonary Resuscitation en
dc.subject Ventricular fibrillation en
dc.subject Beta-blockade en
dc.subject Beta-blockers en
dc.subject Advanced Life Support en
dc.title Use of beta-blockers for the treatment of cardiac arrest due to ventricular fibrillation/pulseless ventricular tachycardia: A systematic review en
dc.type Resenha
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Escola Bahiana Med & Saude Publ
dc.contributor.institution Hosp Santa Izabel
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Escola Bahiana Med & Saude Publ, BR-40050420 Salvador, BA, Brazil
dc.description.affiliation Hosp Santa Izabel, Hosp Santa Izabel Santa Casa de Misericordia Bahi, BR-40050410 Salvador, BA, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Cardiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Cardiol, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.resuscitation.2012.01.025
dc.description.source Web of Science
dc.identifier.wos WOS:000304669700016



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