Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil

Author	Mantovani, N. P. Azevedo, R. G. Rabelato, J. T. Sanabani, S. Diaz, R. S. Komninakis, S. V.
Institution	Universidade Federal de São Paulo (UNIFESP) Lusiada Fdn Santos Universidade de São Paulo (USP)
Abstract	We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.
Language	English
Sponsor	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number	FAPESP: 09/05712-3
Date	2012-06-01
Published in	Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 50, n. 6, p. 2122-2125, 2012.
ISSN	0095-1137 (Sherpa/Romeo, impact factor)
Publisher	Amer Soc Microbiology
Extent	2122-2125
Origin	http://dx.doi.org/10.1128/JCM.00539-12
Access rights	Open access
Type	Article
Web of Science ID	WOS:000305119000056
URI	http://repositorio.unifesp.br/handle/11600/34920