Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil

Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil

Author Mantovani, N. P. Autor UNIFESP Google Scholar
Azevedo, R. G. Autor UNIFESP Google Scholar
Rabelato, J. T. Google Scholar
Sanabani, S. Google Scholar
Diaz, R. S. Autor UNIFESP Google Scholar
Komninakis, S. V. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Lusiada Fdn Santos
Universidade de São Paulo (USP)
Abstract We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 09/05712-3
Date 2012-06-01
Published in Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 50, n. 6, p. 2122-2125, 2012.
ISSN 0095-1137 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 2122-2125
Origin http://dx.doi.org/10.1128/JCM.00539-12
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000305119000056
URI http://repositorio.unifesp.br/handle/11600/34920

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