Exercise Training Decreases Adipose Tissue Inflammation in Cachectic Rats

Exercise Training Decreases Adipose Tissue Inflammation in Cachectic Rats

Author Lira, F. S. Autor UNIFESP Google Scholar
Yamashita, A. S. Google Scholar
Rosa, J. C. Autor UNIFESP Google Scholar
Koyama, C. H. Google Scholar
Caperuto, E. C. Google Scholar
Batista, M. L. Google Scholar
Seelaender, M. C. L. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Abstract Bearing in mind that cancer cachexia is associated with chronic systemic inflammation and that endurance training has been adopted as a nonpharmacological anti-inflammatory strategy, we examined the effect of 8 weeks of moderate intensity exercise upon the balance of anti-and pro-inflammatory cytokines in 2 different depots of white adipose tissue in cachectic tumour-bearing (Walker-256 carcinosarcoma) rats. Animals were assigned to a sedentary control (SC), sedentary tumour-bearing (ST), sedentary pair-fed (SPF) or exercise control (EC), exercise tumour-bearing (ET), and exercise pair-fed (EPF) group. Trained rats ran on a treadmill (60% VO(2)max) 60 min/day, 5 days/week, for 8 weeks. the retroperitoneal (RPAT) and mesenteric (MEAT) adipose pads were excised and the mRNA (RT-PCR) and protein (ELISA) expression of IL-1 beta, IL-6, TNF-alpha, and IL-10 were evaluated. the number of infiltrating monocytes in the adipose tissue was increased in cachectic rats. TNF-alpha mRNA in MEAT was increased in the cachectic animals (p < 0.05) in relation to SC. RPAT protein expression of all studied cytokines was increased in cachectic animals in relation to SC and SPF (p < 0.05). in this pad, IL-10/TNF-alpha ratio was reduced in the cachectic animals in comparison with SC (p < 0.05) indicating inflammation. Exercise training improved IL-10/TNF-alpha ratio and induced a reduction of the infiltrating monocytes both in MEAT and RPAT (p < 0.05), when compared with ST. We conclude that cachexia is associated with inflammation of white adipose tissue and that exercise training prevents this effect in the MEAT, and partially in RPAT.
Keywords cancer-cachexia
adipose tissue
cytokines
exercise training
inflammation
Language English
Date 2012-02-01
Published in Hormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 44, n. 2, p. 91-98, 2012.
ISSN 0018-5043 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 91-98
Origin http://dx.doi.org/10.1055/s-0031-1299694
Access rights Closed access
Type Article
Web of Science ID WOS:000300419400003
URI http://repositorio.unifesp.br/handle/11600/34601

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