Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy: A Microscopic Study Contrasted with the Hormonal Assays

Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy: A Microscopic Study Contrasted with the Hormonal Assays

Author Venancio, Daniel P. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Vilamaior, Patricia S. L. Google Scholar
Santos, Fernanda C. Google Scholar
Zager, Adriano Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Taboga, Sebastiao R. Google Scholar
DeMello, Marco T. Autor UNIFESP Google Scholar
Institution Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás (UFG)
Abstract We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. the significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-01-01
Published in Journal of Biomedicine and Biotechnology. New York: Hindawi Publishing Corporation, 6 p., 2012.
ISSN 1110-7243 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 6
Origin http://dx.doi.org/10.1155/2012/285938
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000308189000001
URI http://repositorio.unifesp.br/handle/11600/34368

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