Early physical exercise and seizure susceptibility later in life

Early physical exercise and seizure susceptibility later in life

Author Silva, Sergio Gomes da Autor UNIFESP Google Scholar
Almeida, Alexandre Aparecido de Autor UNIFESP Google Scholar
Silva Araujo, Bruno Henrique Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We conducted a study to examine whether physical exercise undertaken during the period of postnatal brain development could modify seizure susceptibility later in life. Male Wistar rats aged 21 postnatal days (P21) were divided into two groups: exercise and control. Animals in the exercise group were submitted to daily exercise on the treadmill between P21 and P60. Running time and speed gradually increased over this period, reaching a maximum of 18 m/min for 60min. After the final exercise session (P60), animals from exercise group were maintained non-trained for 90 days. This period without stimulus was used to observe the influence of early physical exercise on susceptibility to seizures induced by the pilocarpine model of epilepsy at P150. the results showed that the exercise program undertaken during the period of postnatal brain development delayed the onset and reduced the intensity of pilocarpine-induced motor symptoms in midlife rats. These findings suggest that early exercise interferes positively in the later ictogenesis process, and support the hypothesis that physical activity in early life may build a neural reserve against brain disorders. (C) 2011 ISDN. Published by Elsevier B.V. All rights reserved.
Keywords Exercise
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Cooperacao Interinstitucional de Apoio a Pesquisa sobre o Cerebro (CInAPCe)
Instituto Nacional de Neurociencia Translacional (INNT) (Brazil)
Date 2011-12-01
Published in International Journal of Developmental Neuroscience. Oxford: Pergamon-Elsevier B.V., v. 29, n. 8, p. 861-865, 2011.
ISSN 0736-5748 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 861-865
Origin http://dx.doi.org/10.1016/j.ijdevneu.2011.07.011
Access rights Closed access
Type Article
Web of Science ID WOS:000297775100011
URI http://repositorio.unifesp.br/handle/11600/34290

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