Assessment of aerobic capacity during swimming exercise in ob/ob mice

Assessment of aerobic capacity during swimming exercise in ob/ob mice

Author Almeida, W. S. Google Scholar
Lima, L. C. J. Google Scholar
Cunha, V. N. C. Google Scholar
Cunha, R. R. Google Scholar
Araujo, R. C. Google Scholar
Barros, C. C. Autor UNIFESP Google Scholar
Simoes, H. G. Google Scholar
Campbell, C. S. G. Google Scholar
Institution Univ Catolica Brasilia
Universidade Federal de São Paulo (UNIFESP)
Abstract Obesity is a highly prevalent condition associated with several diseases. Physical exercise has been considered as a non-pharmacological tool in the treatment of obesity. However, several aspects underlying exercise evaluation and prescription in obesity and associated pathologies are still under investigation. Although many research involving exercise have been performed in animal models, there is a lack of protocols for aerobic capacity assessment in obese animals, such as the ob/ob mice. This study aimed the following: (i) to verify the possibility of determining the lactate threshold (LT) on swimming exercise in ob/ob mice and in non-obese heterozygote mice (ob/OB), through visual inspection (vLT) and polynomial adjustment (pLT); and (ii) to verify if the LT determined through these protocols corresponds to the maximal lactate steady state (MLSS). Eight ob/ob and ten ob/OB mice performed an incremental exercise test to determine vLT and pLT as well as constant-load exercise bouts to determine MLSS. There were no within-group differences between vLT, pLT and MLSS [ob/ob: similar to 5.3% body weight (BW); ob/OB: similar to 3 center dot 6%BW] with a high agreement among protocols. in conclusion, the identification of the LT and MLSS intensities was possible for both groups. These data suggest that the proposed protocols may be used in new research on the effects of different exercise intensities on some aspects of obesity. Copyright (c) 2011 John Wiley & Sons, Ltd.
Keywords aerobic exercise
lactate threshold
leptin
maximal lactate steady state
mice
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CAPES: 0216054
Date 2011-12-01
Published in Cell Biochemistry and Function. Malden: Wiley-Blackwell, v. 29, n. 8, p. 666-672, 2011.
ISSN 0263-6484 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 666-672
Origin http://dx.doi.org/10.1002/cbf.1803
Access rights Closed access
Type Article
Web of Science ID WOS:000297632400007
URI http://repositorio.unifesp.br/handle/11600/34265

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