Biomarkers of Spontaneous Preterm Birth: An Overview of the Literature in the Last Four Decades

Biomarkers of Spontaneous Preterm Birth: An Overview of the Literature in the Last Four Decades

Author Menon, Ramkumar Google Scholar
Torloni, Maria Regina Autor UNIFESP Google Scholar
Voltolini, Chiara Google Scholar
Torricelli, Michela Google Scholar
Merialdi, Mario Google Scholar
Betran, Ana Pilar Google Scholar
Widmer, Mariana Google Scholar
Allen, Tomas Google Scholar
Davydova, Iulia Google Scholar
Khodjaeva, Zulfiya Google Scholar
Thorsen, Poul Google Scholar
Kacerovsky, Marian Google Scholar
Tambor, Vojtich Google Scholar
Massinen, Tytti Google Scholar
Nace, Judith Google Scholar
Arora, Chander Google Scholar
Institution Univ Texas Med Branch
Universidade Federal de São Paulo (UNIFESP)
Univ Siena
Fed Res Ctr Obstet & Gynecol & Perinatol
Lillebaelt Hosp
Hradec Kralove Charles Univ
Perkin Elmer Corp
Univ Tubingen
Cedars Sinai Med Ctr
Abstract Background: Understanding spontaneous preterm birth ([PTB] < 37 weeks) is difficult due to heterogeneities associated with multitudes of risk factors and pathophysiological pathways. Several biomarkers are routinely used clinically for predicting preterm labor; however, these factors are either nonspecific or detected too late. Objective: Systematic review of literature on PTB biomarkers in the last 40 years to map out the existing knowledge and gaps in understanding PTB biomarkers. Search strategies: Five electronic databases were searched for human studies on PTB biomarkers published in any language between 1965 and 2008. Selection criteria: the phenotype of interest for final data extraction was exclusively spontaneous PTB with no rupture of membranes. Data extraction included (a) general characteristics of the study (clinical setting, period, and study design), (b) study/participant characteristics (inclusion and exclusion criteria, race/ethnicity, number of participants, gestational age at sampling, (c) characteristics of the biomarker (type, rationale for its selection, type of biological sample, and assay used, and (d) concentration of biomarkers in cases and controls. Data collection and analysis: the search yielded 7255 citations and data were extracted from 217 articles which met our inclusion and exclusion criteria. Main results: A total of 116 different biomarkers were reported and these were assayed 578 times in the 217 included studies. Over two thirds of the 217 studies were performed on North American or European populations. No reliable biomarkers emerged as a risk predictor of PTB. Conclusions: Identifying similar studies on biomarkers for the prediction of PTB was a very challenging task due heterogeneities in study design, sampling issues (types, timing and processing), assay methods, and analyses. Major areas of concern identified in this review include poor phenotype definition, nonideal study designs and poor rationale for biomarker selection and assays and population stratification issues.
Keywords prematurity
risk factors
Language English
Sponsor PREBIC, Inc.
Date 2011-11-01
Published in Reproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 18, n. 11, p. 1046-1070, 2011.
ISSN 1933-7191 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 1046-1070
Access rights Closed access
Type Review
Web of Science ID WOS:000296206300002

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