Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy

Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy

Author Prado, Wagner Luiz do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Lofrano-Prado, Mara Cristina Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Stella, Sérgio Garcia Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein [AgRP], neuropeptide Y [NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone [alpha-MSH]), in obese adolescents.Methods: A total of 88 adolescents (38 boys and 50 girls), including 62 obese and 26 normal-weight, aged 15-19 years were recruited. Obese adolescents were submitted to a 24-week multidisciplinary therapy. AgRP, NPY, melanin-concentrating hormone, leptin, insulin, glucose, alpha-MSH, total ghrelin, and food intake were measured at three stages (at baseline, after 12 weeks, and after 24 weeks).Results: At baseline, obese adolescents showed hyperleptinemia (circulating leptin levels, which were, in boys and girls, 40 and 35 times higher than in normal-weight subjects, respectively). After 24 weeks, these values decreased in all obese patients. Our results showed no differences in ghrelin levels between obese and normal-weight adolescents, in both genders. However, obese boys reduced their plasma ghrelin concentration after 24 weeks of therapy (p<.05). the multidisciplinary therapy decreased NPY and AgRP values and increased alpha-MSH; simultaneously with these changes there was a decrease in total food intake after 24 weeks of therapy.Conclusions: We can conclude that the multidisciplinary therapy was efficient to modulate neurohormonal control of food intake in obese adolescents. (C) 2011 Society for Adolescent Health and Medicine. All rights reserved.
Keywords Obesity
Food intake
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2006/00684-3
FAPESP: 360#9814303-3
Date 2011-09-01
Published in Journal of Adolescent Health. New York: Elsevier B.V., v. 49, n. 3, p. 300-305, 2011.
ISSN 1054-139X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 300-305
Access rights Closed access
Type Article
Web of Science ID WOS:000294071100012

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