Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?

Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?

Author Mattei, Rita Autor UNIFESP Google Scholar
Polotow, Tatiana Geraldo Google Scholar
Vardaris, Cristina Vasconcellos Google Scholar
Guerra, Beatriz Alves Google Scholar
Leite, Jose Roberto Autor UNIFESP Google Scholar
Otton, Rosemari Google Scholar
Barros, Marcelo Paes de Google Scholar
Institution Univ Cruzeiro Sul
Universidade Federal de São Paulo (UNIFESP)
Abstract The habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Astaxanthin
Omega-3
Anxiety
Fish oil
Antioxidant
Brain
Carotenoid
Elevated plus maze
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
International Foundation for Science
Universidade Cruzeiro do Sul
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Departamento de Psicobiologia, UNIFESP
Grant number FAPESP: 2007/03334-6
FAPESP: 2009/12342-8
FAPESP: 2002/09405-9
International Foundation for Science: F/3816-1
Date 2011-09-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 349-355
Origin http://dx.doi.org/10.1016/j.pbb.2011.05.009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000293371100009
URI http://repositorio.unifesp.br/handle/11600/33974

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