Reciprocal interactions between MK-801, sleep deprivation and recovery in modulating rat behaviour

Reciprocal interactions between MK-801, sleep deprivation and recovery in modulating rat behaviour

Author Dubiela, Francisco Paulino Autor UNIFESP Google Scholar
Messias, Melissa Fudoli Autor UNIFESP Google Scholar
Moreira, Karin Di Monteiro Autor UNIFESP Google Scholar
Zanlorenci, Lineane Helena Fernandes Autor UNIFESP Google Scholar
Grassl, Christian Autor UNIFESP Google Scholar
Frussa Filho, Roberto Autor UNIFESP Google Scholar
Nobrega, Jose N. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Hipólide, Débora Cristina Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Addict & Mental Hlth
Abstract Increasing evidence indicates that sleep deprivation alters behavioural responses to various pharmacological agents which might be associated to changes in receptor systems. the present work addressed the effects of sleep deprivation and recovery on behavioural changes induced by MK-801, and investigated whether such effects are related to changes in NMDA receptor (NMDAR) binding. Male Wistar rats were deprived of sleep for 96 h using the platform method (SD group), or were sleep deprived and then allowed to recover sleep for 24 h (SR group). Animals were treated with saline or 0.05, 0.10 or 0.20 mg/kg MK-801 before testing in an open field arena and elevated plus maze. A separate set of animals was sacrificed for [(3)H]MK-801 binding analysis in 40 brain regions. MK-801-induced hyperlocomotion was facilitated in a dose-dependent fashion after SR, while SD-induced increase in grooming was antagonized by the drug. Anxiolytic effects of 0.05 and 0.10 mg/kg MK-801 were unaffected by SD or SR conditions. No significant differences among groups were found in NMDAR binding. These findings indicate that the combined effects of MK-801 and sleep deprivation and recovery interact in a complex fashion to affect rat behaviour. They further suggest that such effects cannot be attributed to altered NMDAR binding in brain. (C) 2010 Elsevier B.V. All rights reserved.
Keywords Rat
Sleep deprivation
NMDA receptor
Locomotor activity
Language English
Sponsor AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/1403-3
Date 2011-01-01
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 216, n. 1, p. 180-185, 2011.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 180-185
Access rights Closed access
Type Article
Web of Science ID WOS:000285318500024

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