Updated Neuronal Scaling Rules for the Brains of Glires (Rodents/Lagomorphs)

Updated Neuronal Scaling Rules for the Brains of Glires (Rodents/Lagomorphs)

Author Herculano-Houzel, Suzana Google Scholar
Ribeiro, Pedro Google Scholar
Campos, Leandro Google Scholar
Silva, Alexandre Valotta da Autor UNIFESP Google Scholar
Torres, Laila Brito Autor UNIFESP Google Scholar
Catania, Kenneth C. Google Scholar
Kaas, Jon H. Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Vanderbilt Univ
Abstract Brain size scales as different functions of its number of neurons across mammalian orders such as rodents, primates, and insectivores. in rodents, we have previously shown that, across a sample of 6 species, from mouse to capybara, the cerebral cortex, cerebellum and the remaining brain structures increase in size faster than they gain neurons, with an accompanying decrease in neuronal density in these structures [Herculano-Houzel et al.: Proc Natl Acad Sci USA 2006; 103: 12138-12143]. Important remaining questions are whether such neuronal scaling rules within an order apply equally to all pertaining species, and whether they extend to closely related taxa. Here, we examine whether 4 other species of Rodentia, as well as the closely related rabbit (Lagomorpha), conform to the scaling rules identified previously for rodents. We report the updated neuronal scaling rules obtained for the average values of each species in a way that is directly comparable to the scaling rules that apply to primates [Gabi et al.: Brain Behav Evol 2010; 76: 32-44], and examine whether the scaling relationships are affected when phylogenetic relatedness in the dataset is accounted for. We have found that the brains of the spiny rat, squirrel, prairie dog and rabbit conform to the neuronal scaling rules that apply to the previous sample of rodents. the conformity to the previous rules of the new set of species, which includes the rabbit, suggests that the cellular scaling rules we have identified apply to rodents in general, and probably to Glires as a whole (rodents/lagomorphs), with one notable exception: the naked mole-rat brain is apparently an outlier, with only about half of the neurons expected from its brain size in its cerebral cortex and cerebellum. Copyright (C) 2011 S. Karger AG, Basel
Keywords Rodents
Brain size
Evolution
Neurons
Glia
Glires
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
James S. McDonnell Foundation
NSF
NEI
Grant number NSF: 0844743
NEI: EY02686
Date 2011-01-01
Published in Brain Behavior and Evolution. Basel: Karger, v. 78, n. 4, p. 302-314, 2011.
ISSN 0006-8977 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 302-314
Origin http://dx.doi.org/10.1159/000330825
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000297217500005
URI http://repositorio.unifesp.br/handle/11600/33212

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