B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection

B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection

Author Russo, Ricardo T. Google Scholar
Mariano, Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract B-1 cells were first described in the early 1980s and are distinct from conventional B lymphocytes in respect to phenotype, morphology, ontogeny, tissular distribution and function. Although many years have been past since their description, B-1 cells role within the immune system is still unclear. Years ago, our lab demonstrated that B-1 cells were able to differentiate into macrophage-like mononuclear phagocytes that could migrate to the acute inflammatory focus induced by a foreign body in vivo. We also showed that B-1 cells were pivotal for the formation of foreign-body giant cells. Studies using B-1-cell-defiecient mice (Xid mice), suggested B-1 cells have a participation in immune responses to infections. This led us to investigate whether B-1 cells would also have a participation in a model of infection-generated chronic inflammation. Using Xid mice and adoptive transfer of cultured B-1 cells, we investigated the influence of these cells on some of the immune events triggered by Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice. We found that B-1 cells are present in the BCG-induced pulmonary lesions and can migrate from peritoneal cavity to the infected lung, modulate the histological pattern of the inflammation, influence the influx of other cells to the infected lung and favor the resistance to the mycobacteria. Altogether, our results demonstrate that peritoneal B-1 cells play a key role in the inflammatory reaction to BCG, clarifying a new aspect of the biology of these versatile cells. (C) 2010 Elsevier GmbH. All rights reserved.
Keywords B-1 cell
Granuloma
BCG
Protection
Chronic inflammation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2010-12-01
Published in Immunobiology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 215, n. 12, p. 1005-1014, 2010.
ISSN 0171-2985 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1005-1014
Origin http://dx.doi.org/10.1016/j.imbio.2010.01.003
Access rights Closed access
Type Article
Web of Science ID WOS:000285532100009
URI http://repositorio.unifesp.br/handle/11600/33125

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