Genetic damage in multiple organs of acutely exercised rats

Genetic damage in multiple organs of acutely exercised rats

Author Pozzi, Renan Autor UNIFESP Google Scholar
Rosa, Jose C. Autor UNIFESP Google Scholar
Eguchi, Ricardo Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia M. Autor UNIFESP Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Aguiar, Odair Autor UNIFESP Google Scholar
Chaves, Marcelo D. Autor UNIFESP Google Scholar
Ribeiro, Daniel A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to investigate the effects of acute exercise on genomic damage in an animal model. Male adult Wistar rats were divided into the following groups: control and acute exercised (experimental). for this purpose, 15 animals were accustomed to running on a rodent treadmill for 15 min per day for 5 days (10-20 m min(-1); 08 grade). After 4 days at rest, active animals ran on the treadmill (22 m min(-1), 58 grade) till exhaustion. Cells from peripheral blood, liver, heart, and brain were collected after 0, 2, and 6 h after exercise. the results showed that acute exercise was able to induce genetic damage in peripheral blood cells after 2 and 6 h of exercise, whereas liver pointed out genetic damage for all periods evaluated. No genetic damage was induced either in brain or in heart cells. in conclusion, our results suggest that acute exercise could contribute to the genetic damage in peripheral blood and liver cells. It seems that liver is a sensitive organ to the genotoxic insult after acute exercise. Copyright (C) 2010 John Wiley & Sons, Ltd.
Keywords acute exercise
single-cell gel (comet) assay
DNA damage
rats
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/01228-4
CNPq: 561357/2008-0
Date 2010-12-01
Published in Cell Biochemistry and Function. Chichester: John Wiley & Sons Ltd, v. 28, n. 8, p. 632-636, 2010.
ISSN 0263-6484 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 632-636
Origin http://dx.doi.org/10.1002/cbf.1700
Access rights Closed access
Type Article
Web of Science ID WOS:000284716200002
URI http://repositorio.unifesp.br/handle/11600/33107

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