Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats

Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats

Author Da Silva, Adelino S. R. Google Scholar
Pauli, José Rodrigo Autor UNIFESP Google Scholar
Ropelle, Eduardo R. Google Scholar
Oliveira, Alexandre G. Google Scholar
Cintra, Dennys E. Google Scholar
De Souza, Claudio T. Google Scholar
Velloso, Licio A. Google Scholar
Carvalheira, Jose B. C. Google Scholar
Saad, Mario J. A. Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ So Santa Catarina
Abstract DA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.
Keywords OBESITY
ACUTE EXERCISE
INSULIN SIGNALING
INFLAMMATION
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2006/06961-9
FAPESP: 2006/06960-2
Date 2010-12-01
Published in Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010.
ISSN 0195-9131 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 2180-2188
Origin http://dx.doi.org/10.1249/MSS.0b013e3181e45d08
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000284353500005
URI http://repositorio.unifesp.br/handle/11600/33097

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