Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension

Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension

Author Motta, D. F. Google Scholar
Lima, L. C. J. Google Scholar
Arsa, G. Google Scholar
Russo, P. S. Google Scholar
Sales, M. M. Google Scholar
Moreira, S. R. Google Scholar
Morais, P. K. Google Scholar
Almeida, W. S. Google Scholar
Araujo, R. C. Autor UNIFESP Google Scholar
Moraes, M. R. Autor UNIFESP Google Scholar
Pesquero, J. L. Google Scholar
Simoes, H. G. Google Scholar
Campbell, C. S. G. Google Scholar
Institution Univ Catolica Brasilia
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Vale do Sao Francisco
Abstract Aim.-The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH).Methods. - Ten T2D patients (age: 53.6 +/- 1.3 years; body mass index: 30.6 +/- 1.0 kg/m(2); resting blood glucose: 157.8 +/- 40.2 mg dL(-1)) and 10 non-diabetic (ND) volunteers (age: 47.5 +/- 1.0 years; body mass index: 28.3 +/- 0.9 kg/m(2); resting blood glucose: 91.2 +/- 10.5 mg dL(-1)) underwent two experimental sessions, consisting of 20 mm of rest plus 20 min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3ACI-1 monitor) and PKA were measured during rest and every 15 min for 135 min of the postexercise recovery period (RP).Results. - During the RP, the ND individuals presented with PEH at 30, 45 and 120 min (P < 0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15 min postexercise in the ND (P < 0.05), but not in the T2D patients.Conclusion. - T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH. (C) 2010 Elsevier Masson SAS. All rights reserved.
Keywords Post-exercise hypotension
Type 2 diabetes
Blood pressure
Kallikrein activity
lactate threshold
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CAPES: 0216054
Date 2010-11-01
Published in Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 36, n. 5, p. 363-368, 2010.
ISSN 1262-3636 (Sherpa/Romeo, impact factor)
Publisher Masson Editeur
Extent 363-368
Origin http://dx.doi.org/10.1016/j.diabet.2010.03.008
Access rights Closed access
Type Article
Web of Science ID WOS:000285399900006
URI http://repositorio.unifesp.br/handle/11600/33035

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