Controlled transscleral drug delivery formulations to the eye: establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis

Controlled transscleral drug delivery formulations to the eye: establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis

Author Paganelli, Fernando Autor UNIFESP Google Scholar
Cardillo, Jose A. Autor UNIFESP Google Scholar
Dare, Alessandro R. J. Google Scholar
Melo, Luiz A. S. Autor UNIFESP Google Scholar
Lucena, David R. Google Scholar
Silva, Arnobio A. Google Scholar
Oliveira, Anselmo G. Google Scholar
Pizzolitto, Antonio C. Google Scholar
Lavinsky, Daniel Autor UNIFESP Google Scholar
Skaf, Mirian Google Scholar
Souza-Filho, Acacio A. Autor UNIFESP Google Scholar
Hofling-Lima, Ana L. Autor UNIFESP Google Scholar
Nguyen, Quan Dong Google Scholar
Kuppermann, Baruch D. Google Scholar
Herrero-Vanrell, Rocio Google Scholar
Belfort, Rubens Autor UNIFESP Google Scholar
Brazilian Ocular Pharmacoloy & Pha Google Scholar
Institution Hosp Olhos Araraquara
Universidade Federal de São Paulo (UNIFESP)
Univ Araraquara UNIARA
São Paulo State Univ UNESP
Johns Hopkins Univ
Univ Calif Irvine
Univ Complutense
Abstract Importance of the field: the use of topical agents poses unique and challenging hurdles for drug delivery. Topical steroids effectively control ocular inflammation, but are associated with the well-recognized dilemma of patient compliance. Although administration of topical antimicrobials as prophylaxis is acceptable among ophthalmologists, this common practice has no sound evidence base Developing a new antimicrobial agent or delivery strategy with enhanced penetration by considering the anatomical and physiological constraints exerted by the barriers of the eye is not a commonly perceived strategy. Exploiting the permeability of the sclera, subconjunctival routes may offer a promising alternative for enhanced drug delivery and tissue targeting.Area covered in this review: Ocular drug delivery strategies were reviewed for ocular inflammation and infections clinically adopted for newer class of antimicrobials, which use a multipronged approach to limit risks of endophthalmitis.What the reader will gain: the analysis substantiates a new transscleral drug delivery therapeutic approach for cataract surgery.Take home message: A new anti-inflammatory and anti-infective paradigm that frees the patient from the nuisance of topical therapeutics is introduced, opening a large investigative avenue for future improved therapies.
Keywords antibiotics
antimicrobials
cataract surgery
endophthalimitis
eye drops
eye infections
intraocular penetration
ocular drug delivery
Language English
Date 2010-08-01
Published in Expert Opinion On Drug Delivery. London: Informa Healthcare, v. 7, n. 8, p. 955-965, 2010.
ISSN 1742-5247 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 955-965
Origin http://dx.doi.org/10.1517/17425247.2010.498817
Access rights Closed access
Type Review
Web of Science ID WOS:000281032400006
URI http://repositorio.unifesp.br/handle/11600/32809

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