Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Author Carlin, Viviane Autor UNIFESP Google Scholar
Artioli, A. J. Google Scholar
Matsumoto, M. A. Google Scholar
Filho, H. N. Google Scholar
Borgo, E. Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Sagrado Coracao Univ
Universidade de São Paulo (USP)
Abstract Objectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure.Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included.Results: No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. in contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05).Conclusion: in summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 295-299. doi: 10.1259/dmfr/17573156
Keywords buccal mucosa cells
cone beam computed tomography
micronucleus test
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/00345-7
FAPESP: 07/01228-4
Date 2010-07-01
Published in Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 5, p. 295-299, 2010.
ISSN 0250-832X (Sherpa/Romeo, impact factor)
Publisher British Inst Radiology
Extent 295-299
Origin http://dx.doi.org/10.1259/dmfr/17573156
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000279343500007
URI http://repositorio.unifesp.br/handle/11600/32654

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