Seroepidemiological Survey of Paracoccidioidomycosis Infection Among Urban and Rural Dogs from Uberaba, Minas Gerais, Brazil

Seroepidemiological Survey of Paracoccidioidomycosis Infection Among Urban and Rural Dogs from Uberaba, Minas Gerais, Brazil

Author Fontana, Fabricio Fernandes Google Scholar
Barbosa dos Santos, Celso Tadeu Google Scholar
Esteves, Flavia Maria Google Scholar
Rocha, Ademir Google Scholar
Fernandes, Geisa Ferreira Autor UNIFESP Google Scholar
Amaral, Cristiane Candida do Autor UNIFESP Google Scholar
Domingues, Marcos Abel Google Scholar
De Camargo, Zoilo Pires Autor UNIFESP Google Scholar
Silva-Vergara, Mario Leon Google Scholar
Institution Univ Fed Triangulo Mineiro
Municipal Ctr Zoonoses
Universidade Federal de Uberlândia (UFU)
Universidade Federal de São Paulo (UNIFESP)
Abstract There is some evidence that dogs can be naturally infected by Paracoccidioides brasiliensis in endemic areas of paracoccidioidomycosis. in order to evaluate canine infection with this fungus, a survey with 149 urban and 126 rural dogs was carried out using ELISA and intradermal tests with the gp43 antigen of P. brasiliensis in Uberaba, Minas Gerais state of Brazil. Forty-one out of 149 urban dogs were euthanatized and had their lungs, liver and spleen removed. One slice from each viscera was processed for histopathological examination and the remaining was homogenized and then cultivated on mycobiotic agar at room temperature and Fava-Netto medium at 35A degrees C and observed for 12 weeks. of urban dogs, 75 (50.3%) were small adult females, 56 (36%) were strays, while 93 (64%) had been donated to the municipal zoonosis control center. Nine (6.2%) had a positive intradermal test without statistical differences regarding gender, race, nutritional status or origin. No colonies with microscopic or morphology appearances resembling P. brasiliensis were isolated, nor granulomatous process or fungal structures were observed from histopathological examination. Eighty (53.6%) of the urban dogs presented seroreactivity, without statistical differences regarding gender, race, nutritional state, origin, or positive intradermal test. of 126 rural dogs, 102 (80.5%) presented antibodies against gp43 antigen, and this was statistically significant in relation to the reactivity detected in urban dogs (P = 0.0001). Thus, dogs are commonly infected with P. brasiliensis, but they probably present natural resistance to develop paracoccidioidomycosis.
Keywords Paracoccidioidomycosis
Paracoccidioides brasiliensis
ELISA gp43
Language English
Sponsor Research Support Foundation of the State of Minas Gerais
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-03-01
Published in Mycopathologia. Dordrecht: Springer, v. 169, n. 3, p. 159-165, 2010.
ISSN 0301-486X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 159-165
Access rights Closed access
Type Article
Web of Science ID WOS:000274656900002

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