Amnestic effect of cocaine after the termination of its stimulant action

Amnestic effect of cocaine after the termination of its stimulant action

Author Niigaki, S. T. Autor UNIFESP Google Scholar
Silva, R. H. Google Scholar
Patti, C. L. Autor UNIFESP Google Scholar
Cunha, J. L. S. Autor UNIFESP Google Scholar
Kameda, S. R. Autor UNIFESP Google Scholar
Correia-Pinto, J. C. Autor UNIFESP Google Scholar
Takatsu-Coleman, A. L. Autor UNIFESP Google Scholar
Levin, R. Autor UNIFESP Google Scholar
Abilio, V. C. Autor UNIFESP Google Scholar
Frussa-Filho, R. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Norte
Abstract The effects of cocaine on memory are controversial. Furthermore, the psychostimulant action of cocaine can be a critical issue in the interpretation of its effects on learning/memory models. the effects of a single administration of cocaine on memory were investigated during the presence of its motor stimulating effect or just after its termination. the plus-maze discriminative avoidance task (PM-DAT) was used because it provides simultaneous information about memory, anxiety and motor activity. in Experiment I, mice received saline, 7.5, 10, 15 or 30 mg/kg cocaine 5 min before the training session. in Experiment II, mice were trained 30 min after the injection of saline, 7.5, 10, 15 or 30 mg/kg cocaine. in Experiment III, mice received 30 mg/kg cocaine 30 min pre-training and pre-test. in Experiment IV, mice received 30 mg/kg cocaine immediately post-training. Tests were always conduced 24 h following the training session. Given 5 min before training, cocaine promoted a motor stimulant effect at the highest dose during the training session but did not impair memory. When cocaine was injected 30 min pre-training, the drug did not modify motor activity, but produced marked amnestic effects at all doses tested. This amnesia induced by cocaine given 30 min pre-training was not related to a state-dependent learning because it was not abolished by pretest administration of the drug. Post-training cocaine administration did not induce memory deficits either. Our results suggest that the post-stimulant phase is the critical moment for cocaine-induced memory deficit in a discriminative task in mice. (C) 2009 Published by Elsevier Inc.
Keywords Cocaine
Memory
Psychostimulant effect
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundo de Auxilio ao Docente e Aluno da UNIFESP (FADA)
Associacao Fundo de Pesquisa em Psicobiologia (AFIP)
Associacao Fundo de Incentivo Psicofarmacologia (AFIP)
Date 2010-02-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 34, n. 1, p. 212-218, 2010.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 212-218
Origin http://dx.doi.org/10.1016/j.pnpbp.2009.11.010
Access rights Closed access
Type Review
Web of Science ID WOS:000274563400036
URI http://repositorio.unifesp.br/handle/11600/32230

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